node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM2 | ADAM20 | ENSSSCP00000016751 | ENSSSCP00000036851 | Fertilin beta. | ADAM metallopeptidase domain 20. | 0.858 |
ADAM2 | OVGP1 | ENSSSCP00000016751 | ENSSSCP00000039660 | Fertilin beta. | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. | 0.603 |
ADAM2 | SPAM1 | ENSSSCP00000016751 | ENSSSCP00000017585 | Fertilin beta. | Hyaluronidase. | 0.786 |
ADAM2 | ZP2 | ENSSSCP00000016751 | ENSSSCP00000008380 | Fertilin beta. | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. | 0.655 |
ADAM2 | ZP3 | ENSSSCP00000016751 | ENSSSCP00000008213 | Fertilin beta. | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. | 0.697 |
ADAM2 | ZP4 | ENSSSCP00000016751 | ENSSSCP00000010814 | Fertilin beta. | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.730 |
ADAM20 | ADAM2 | ENSSSCP00000036851 | ENSSSCP00000016751 | ADAM metallopeptidase domain 20. | Fertilin beta. | 0.858 |
ADAM20 | OVGP1 | ENSSSCP00000036851 | ENSSSCP00000039660 | ADAM metallopeptidase domain 20. | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. | 0.507 |
ADAM20 | SPAM1 | ENSSSCP00000036851 | ENSSSCP00000017585 | ADAM metallopeptidase domain 20. | Hyaluronidase. | 0.625 |
ADAM20 | ZP2 | ENSSSCP00000036851 | ENSSSCP00000008380 | ADAM metallopeptidase domain 20. | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. | 0.506 |
ADAM20 | ZP3 | ENSSSCP00000036851 | ENSSSCP00000008213 | ADAM metallopeptidase domain 20. | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. | 0.582 |
ADAM20 | ZP4 | ENSSSCP00000036851 | ENSSSCP00000010814 | ADAM metallopeptidase domain 20. | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.610 |
CLRN1 | HTR1D | ENSSSCP00000051069 | ENSSSCP00000069634 | Clarin 1. | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] | 0.669 |
CLRN1 | PPIP5K1 | ENSSSCP00000051069 | ENSSSCP00000038438 | Clarin 1. | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.776 |
CLRN1 | ZP4 | ENSSSCP00000051069 | ENSSSCP00000010814 | Clarin 1. | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.628 |
HTR1D | CLRN1 | ENSSSCP00000069634 | ENSSSCP00000051069 | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] | Clarin 1. | 0.669 |
HTR1D | PPIP5K1 | ENSSSCP00000069634 | ENSSSCP00000038438 | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] | 0.670 |
HTR1D | ZP4 | ENSSSCP00000069634 | ENSSSCP00000010814 | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] | Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. | 0.587 |
OVGP1 | ADAM2 | ENSSSCP00000039660 | ENSSSCP00000016751 | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. | Fertilin beta. | 0.603 |
OVGP1 | ADAM20 | ENSSSCP00000039660 | ENSSSCP00000036851 | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. | ADAM metallopeptidase domain 20. | 0.507 |