Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACTN2Uncharacterized protein. (933 aa)    
Predicted Functional Partners:
ACTN3
Actinin alpha 3 (gene/pseudogene).
  
0.999
TNNI1
Troponin I1, slow skeletal type.
   
 0.953
MYOZ1
Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).
   
 
 0.921
VCL
Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.
   
 0.902
CSRP3
Uncharacterized protein.
   
 0.893
MYOZ2
Calsarcin 1.
   
 
 0.891
TNNT2
Uncharacterized protein.
   
 0.884
MYL2
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform.
   
 0.875
PDLIM1
Uncharacterized protein.
   
 
 0.873
TNNI3
Troponin I3, cardiac type.
   
 0.873
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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