ERO1B protein (Sus scrofa) - STRING interaction network

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Score

ERO1B

Endoplasmic reticulum oxidoreductase 1 beta. (507 aa)

Predicted Functional Partners:

PDIA4

0.966

P4HB

0.955

PDIA6

0.939

TXNDC5

0.937

ERO1A

0.925

ERP29

0.912

HSPA5

0.671

EDEM1

0.598

HERPUD1

0.584

PDIA2

0.580

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDEM1	ERO1A	ENSSSCP00000034590	ENSSSCP00000051791	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	0.509
EDEM1	ERO1B	ENSSSCP00000034590	ENSSSCP00000010823	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Endoplasmic reticulum oxidoreductase 1 beta.	0.598
EDEM1	HERPUD1	ENSSSCP00000034590	ENSSSCP00000056038	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.522
EDEM1	HSPA5	ENSSSCP00000034590	ENSSSCP00000055982	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.712
EDEM1	P4HB	ENSSSCP00000034590	ENSSSCP00000068719	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Protein disulfide-isomerase.	0.461
EDEM1	PDIA2	ENSSSCP00000034590	ENSSSCP00000040399	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Protein disulfide isomerase family A member 2.	0.424
EDEM1	PDIA4	ENSSSCP00000034590	ENSSSCP00000016385	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Protein disulfide-isomerase.	0.602
EDEM1	PDIA6	ENSSSCP00000034590	ENSSSCP00000009202	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Uncharacterized protein; Belongs to the protein disulfide isomerase family.	0.505
ERO1A	EDEM1	ENSSSCP00000051791	ENSSSCP00000034590	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.509
ERO1A	ERO1B	ENSSSCP00000051791	ENSSSCP00000010823	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Endoplasmic reticulum oxidoreductase 1 beta.	0.925
ERO1A	ERP29	ENSSSCP00000051791	ENSSSCP00000010555	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase.	0.915
ERO1A	HSPA5	ENSSSCP00000051791	ENSSSCP00000055982	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.685
ERO1A	P4HB	ENSSSCP00000051791	ENSSSCP00000068719	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Protein disulfide-isomerase.	0.973
ERO1A	PDIA2	ENSSSCP00000051791	ENSSSCP00000040399	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Protein disulfide isomerase family A member 2.	0.580
ERO1A	PDIA4	ENSSSCP00000051791	ENSSSCP00000016385	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Protein disulfide-isomerase.	0.965
ERO1A	PDIA6	ENSSSCP00000051791	ENSSSCP00000009202	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Uncharacterized protein; Belongs to the protein disulfide isomerase family.	0.945
ERO1A	TXNDC5	ENSSSCP00000051791	ENSSSCP00000046853	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	Thioredoxin domain containing 5.	0.937
ERO1B	EDEM1	ENSSSCP00000010823	ENSSSCP00000034590	Endoplasmic reticulum oxidoreductase 1 beta.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.598
ERO1B	ERO1A	ENSSSCP00000010823	ENSSSCP00000051791	Endoplasmic reticulum oxidoreductase 1 beta.	ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...]	0.925
ERO1B	ERP29	ENSSSCP00000010823	ENSSSCP00000010555	Endoplasmic reticulum oxidoreductase 1 beta.	Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase.	0.912