STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1288 aa)    
Predicted Functional Partners:
KCNMB4
Potassium calcium-activated channel subfamily M regulatory beta subunit 4.
    
 
 0.985
KCNN4
Intermediate conductance calcium-activated potassium channel protein 4.
   
  
 0.826
KCNMB1
Potassium calcium-activated channel subfamily M regulatory beta subunit 1.
   
 
 0.807
LRRC26
Leucine rich repeat containing 26.
    
 
 0.695
KCNN3
Small conductance calcium-activated potassium channel protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
   
  
 0.652
TBCB
Cytoskeleton-associated protein 1.
      
 0.632
CDH10
Cadherin-10 isoform X1; Cadherins are calcium-dependent cell adhesion proteins.
      
 0.603
KCNQ4
Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.
   
  
 0.592
CHRNA4
Cholinergic receptor nicotinic alpha 4 subunit.
   
  
 0.584
KCNMB3
Potassium calcium-activated channel subfamily M regulatory beta subunit 3; Belongs to the class-I aminoacyl-tRNA synthetase family.
    
 
 0.583
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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