node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA7 | APP | ENSSSCP00000037695 | ENSSSCP00000012805 | ATP binding cassette subfamily A member 7. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.473 |
ABCA7 | BACE1 | ENSSSCP00000037695 | ENSSSCP00000016002 | ATP binding cassette subfamily A member 7. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.403 |
ABCA7 | PSEN1 | ENSSSCP00000037695 | ENSSSCP00000002538 | ATP binding cassette subfamily A member 7. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.654 |
ABCA7 | PSEN2 | ENSSSCP00000037695 | ENSSSCP00000051215 | ATP binding cassette subfamily A member 7. | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.735 |
APH1A | APH1B | ENSSSCP00000049603 | ENSSSCP00000070557 | Aph-1 homolog A, gamma-secretase subunit. | Aph-1 homolog B, gamma-secretase subunit. | 0.911 |
APH1A | APP | ENSSSCP00000049603 | ENSSSCP00000012805 | Aph-1 homolog A, gamma-secretase subunit. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.635 |
APH1A | F1RM64_PIG | ENSSSCP00000049603 | ENSSSCP00000022017 | Aph-1 homolog A, gamma-secretase subunit. | Uncharacterized protein. | 0.859 |
APH1A | NCSTN | ENSSSCP00000049603 | ENSSSCP00000034430 | Aph-1 homolog A, gamma-secretase subunit. | Nicastrin isoform 1. | 0.996 |
APH1A | PSEN1 | ENSSSCP00000049603 | ENSSSCP00000002538 | Aph-1 homolog A, gamma-secretase subunit. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.994 |
APH1A | PSEN2 | ENSSSCP00000049603 | ENSSSCP00000051215 | Aph-1 homolog A, gamma-secretase subunit. | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.967 |
APH1A | PSENEN | ENSSSCP00000049603 | ENSSSCP00000047698 | Aph-1 homolog A, gamma-secretase subunit. | Presenilin enhancer, gamma-secretase subunit. | 0.992 |
APH1B | APH1A | ENSSSCP00000070557 | ENSSSCP00000049603 | Aph-1 homolog B, gamma-secretase subunit. | Aph-1 homolog A, gamma-secretase subunit. | 0.911 |
APH1B | APP | ENSSSCP00000070557 | ENSSSCP00000012805 | Aph-1 homolog B, gamma-secretase subunit. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.701 |
APH1B | BACE1 | ENSSSCP00000070557 | ENSSSCP00000016002 | Aph-1 homolog B, gamma-secretase subunit. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.561 |
APH1B | F1RM64_PIG | ENSSSCP00000070557 | ENSSSCP00000022017 | Aph-1 homolog B, gamma-secretase subunit. | Uncharacterized protein. | 0.859 |
APH1B | NCSTN | ENSSSCP00000070557 | ENSSSCP00000034430 | Aph-1 homolog B, gamma-secretase subunit. | Nicastrin isoform 1. | 0.995 |
APH1B | PSEN1 | ENSSSCP00000070557 | ENSSSCP00000002538 | Aph-1 homolog B, gamma-secretase subunit. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.994 |
APH1B | PSEN2 | ENSSSCP00000070557 | ENSSSCP00000051215 | Aph-1 homolog B, gamma-secretase subunit. | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] | 0.984 |
APH1B | PSENEN | ENSSSCP00000070557 | ENSSSCP00000047698 | Aph-1 homolog B, gamma-secretase subunit. | Presenilin enhancer, gamma-secretase subunit. | 0.993 |
APP | ABCA7 | ENSSSCP00000012805 | ENSSSCP00000037695 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | ATP binding cassette subfamily A member 7. | 0.473 |