STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APTXAprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (356 aa)    
Predicted Functional Partners:
XRCC1
X-ray repair cross complementing 1.
    
 
 0.862
PARP2
Poly [ADP-ribose] polymerase.
   
 
 0.833
LIG4
DNA ligase.
   
 
 0.781
TDP1
Tyrosyl-DNA phosphodiesterase 1.
    
 
 0.763
CCDC61
Coiled-coil domain-containing protein 61 isoform X1.
      
 0.723
SETX
Senataxin.
   
  
 0.718
PNKP
Polynucleotide kinase 3'-phosphatase.
    
 
0.706
DIP2C
Disco interacting protein 2 homolog C.
      
 0.689
DCAF12
DDB1 and CUL4 associated factor 12.
      
 0.685
APLF
Aprataxin and PNKP like factor.
      
 0.661
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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