| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APLF | APTX | ENSSSCP00000049941 | ENSSSCP00000068010 | Aprataxin and PNKP like factor. | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | 0.661 |
| APLF | LIG4 | ENSSSCP00000049941 | ENSSSCP00000010186 | Aprataxin and PNKP like factor. | DNA ligase. | 0.783 |
| APLF | PARP2 | ENSSSCP00000049941 | ENSSSCP00000002342 | Aprataxin and PNKP like factor. | Poly [ADP-ribose] polymerase. | 0.780 |
| APLF | PNKP | ENSSSCP00000049941 | ENSSSCP00000067414 | Aprataxin and PNKP like factor. | Polynucleotide kinase 3'-phosphatase. | 0.571 |
| APLF | TDP1 | ENSSSCP00000049941 | ENSSSCP00000069555 | Aprataxin and PNKP like factor. | Tyrosyl-DNA phosphodiesterase 1. | 0.640 |
| APLF | XRCC1 | ENSSSCP00000049941 | ENSSSCP00000035475 | Aprataxin and PNKP like factor. | X-ray repair cross complementing 1. | 0.852 |
| APTX | APLF | ENSSSCP00000068010 | ENSSSCP00000049941 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Aprataxin and PNKP like factor. | 0.661 |
| APTX | CCDC61 | ENSSSCP00000068010 | ENSSSCP00000003356 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Coiled-coil domain-containing protein 61 isoform X1. | 0.723 |
| APTX | DCAF12 | ENSSSCP00000068010 | ENSSSCP00000020402 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | DDB1 and CUL4 associated factor 12. | 0.685 |
| APTX | DIP2C | ENSSSCP00000068010 | ENSSSCP00000011911 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Disco interacting protein 2 homolog C. | 0.689 |
| APTX | LIG4 | ENSSSCP00000068010 | ENSSSCP00000010186 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | DNA ligase. | 0.781 |
| APTX | PARP2 | ENSSSCP00000068010 | ENSSSCP00000002342 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Poly [ADP-ribose] polymerase. | 0.833 |
| APTX | PNKP | ENSSSCP00000068010 | ENSSSCP00000067414 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Polynucleotide kinase 3'-phosphatase. | 0.706 |
| APTX | SETX | ENSSSCP00000068010 | ENSSSCP00000006132 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Senataxin. | 0.718 |
| APTX | TDP1 | ENSSSCP00000068010 | ENSSSCP00000069555 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | Tyrosyl-DNA phosphodiesterase 1. | 0.763 |
| APTX | XRCC1 | ENSSSCP00000068010 | ENSSSCP00000035475 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | X-ray repair cross complementing 1. | 0.862 |
| CCDC61 | APTX | ENSSSCP00000003356 | ENSSSCP00000068010 | Coiled-coil domain-containing protein 61 isoform X1. | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] | 0.723 |
| CCDC61 | DCAF12 | ENSSSCP00000003356 | ENSSSCP00000020402 | Coiled-coil domain-containing protein 61 isoform X1. | DDB1 and CUL4 associated factor 12. | 0.463 |
| CCDC61 | LIG4 | ENSSSCP00000003356 | ENSSSCP00000010186 | Coiled-coil domain-containing protein 61 isoform X1. | DNA ligase. | 0.723 |
| CCDC61 | PNKP | ENSSSCP00000003356 | ENSSSCP00000067414 | Coiled-coil domain-containing protein 61 isoform X1. | Polynucleotide kinase 3'-phosphatase. | 0.859 |