node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGLAP | COL10A1 | ENSSSCP00000006920 | ENSSSCP00000004785 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Type X collagen. | 0.645 |
BGLAP | IBSP | ENSSSCP00000006920 | ENSSSCP00000029623 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.658 |
BGLAP | IHH | ENSSSCP00000006920 | ENSSSCP00000017167 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.493 |
BGLAP | PTH | ENSSSCP00000006920 | ENSSSCP00000014236 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | 0.754 |
BGLAP | PTH1R | ENSSSCP00000006920 | ENSSSCP00000072505 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. | 0.585 |
BGLAP | PTHLH | ENSSSCP00000006920 | ENSSSCP00000045438 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Parathyroid hormone like hormone. | 0.528 |
COL10A1 | BGLAP | ENSSSCP00000004785 | ENSSSCP00000006920 | Type X collagen. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.645 |
COL10A1 | IBSP | ENSSSCP00000004785 | ENSSSCP00000029623 | Type X collagen. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.532 |
COL10A1 | IHH | ENSSSCP00000004785 | ENSSSCP00000017167 | Type X collagen. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.785 |
COL10A1 | PTH1R | ENSSSCP00000004785 | ENSSSCP00000072505 | Type X collagen. | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. | 0.604 |
COL10A1 | PTHLH | ENSSSCP00000004785 | ENSSSCP00000045438 | Type X collagen. | Parathyroid hormone like hormone. | 0.514 |
CRH | PTH1R | ENSSSCP00000006626 | ENSSSCP00000072505 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. | 0.592 |
CRH | PTH2R | ENSSSCP00000006626 | ENSSSCP00000017107 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.512 |
IBSP | BGLAP | ENSSSCP00000029623 | ENSSSCP00000006920 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.658 |
IBSP | COL10A1 | ENSSSCP00000029623 | ENSSSCP00000004785 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | Type X collagen. | 0.532 |
IBSP | IHH | ENSSSCP00000029623 | ENSSSCP00000017167 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.506 |
IBSP | PTH1R | ENSSSCP00000029623 | ENSSSCP00000072505 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. | 0.581 |
IHH | BGLAP | ENSSSCP00000017167 | ENSSSCP00000006920 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.493 |
IHH | COL10A1 | ENSSSCP00000017167 | ENSSSCP00000004785 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Type X collagen. | 0.785 |
IHH | IBSP | ENSSSCP00000017167 | ENSSSCP00000029623 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.506 |