STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC100736951Uncharacterized protein. (177 aa)    
Predicted Functional Partners:
NPG1
Prophenin-2; Exerts antimicrobial activity. It is more effective against Gram-negative bacteria than Gram-positive bacteria; Belongs to the cathelicidin family.
   
   
0.786
LOC102159373
Uncharacterized protein.
   
   
0.786
LOC110255221
Antibacterial peptide PMAP-37; Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes; Belongs to the cathelicidin family.
   
   
0.786
PMAP-36
Antibacterial peptide PMAP-36; Exerts antimicrobial activity against both Gram-positive and negative bacteria. Its activity appears to be mediated by its ability to damage bacterial membranes; Belongs to the cathelicidin family.
   
   
0.659
S100A9
EF-hand domain-containing protein; Belongs to the S-100 family.
   
  
 0.520
S100A12
Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...]
   
  
 0.519
PGD
6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
      
 0.433
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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