LRIG1 protein (Sus scrofa) - STRING interaction network

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Score

LRIG1

Leucine rich repeats and immunoglobulin like domains 1. (1112 aa)

Predicted Functional Partners:

MET

0.960

EGFR

0.938

OLFM4

0.829

BMI1

0.823

ERBB2

0.822

LRIG3

0.806

LRIG2

0.796

ASCL2

0.793

HOPX

0.657

CBL

0.656

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL2	BMI1	ENSSSCP00000054800	ENSSSCP00000011820	BHLH domain-containing protein.	RING-type domain-containing protein.	0.614
ASCL2	HOPX	ENSSSCP00000054800	ENSSSCP00000071022	BHLH domain-containing protein.	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	0.519
ASCL2	LRIG1	ENSSSCP00000054800	ENSSSCP00000012255	BHLH domain-containing protein.	Leucine rich repeats and immunoglobulin like domains 1.	0.793
ASCL2	OLFM4	ENSSSCP00000054800	ENSSSCP00000010084	BHLH domain-containing protein.	Olfactomedin 4.	0.898
BMI1	ASCL2	ENSSSCP00000011820	ENSSSCP00000054800	RING-type domain-containing protein.	BHLH domain-containing protein.	0.614
BMI1	HOPX	ENSSSCP00000011820	ENSSSCP00000071022	RING-type domain-containing protein.	Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...]	0.565
BMI1	LRIG1	ENSSSCP00000011820	ENSSSCP00000012255	RING-type domain-containing protein.	Leucine rich repeats and immunoglobulin like domains 1.	0.823
BMI1	OLFM4	ENSSSCP00000011820	ENSSSCP00000010084	RING-type domain-containing protein.	Olfactomedin 4.	0.816
CBL	EGFR	ENSSSCP00000033673	ENSSSCP00000068369	Cbl proto-oncogene.	Receptor protein-tyrosine kinase.	0.999
CBL	ERBB2	ENSSSCP00000033673	ENSSSCP00000018545	Cbl proto-oncogene.	Receptor protein-tyrosine kinase.	0.892
CBL	LRIG1	ENSSSCP00000033673	ENSSSCP00000012255	Cbl proto-oncogene.	Leucine rich repeats and immunoglobulin like domains 1.	0.656
CBL	MET	ENSSSCP00000033673	ENSSSCP00000017620	Cbl proto-oncogene.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.997
EGFR	CBL	ENSSSCP00000068369	ENSSSCP00000033673	Receptor protein-tyrosine kinase.	Cbl proto-oncogene.	0.999
EGFR	ERBB2	ENSSSCP00000068369	ENSSSCP00000018545	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.997
EGFR	LRIG1	ENSSSCP00000068369	ENSSSCP00000012255	Receptor protein-tyrosine kinase.	Leucine rich repeats and immunoglobulin like domains 1.	0.938
EGFR	MET	ENSSSCP00000068369	ENSSSCP00000017620	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.991
ERBB2	CBL	ENSSSCP00000018545	ENSSSCP00000033673	Receptor protein-tyrosine kinase.	Cbl proto-oncogene.	0.892
ERBB2	EGFR	ENSSSCP00000018545	ENSSSCP00000068369	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.997
ERBB2	LRIG1	ENSSSCP00000018545	ENSSSCP00000012255	Receptor protein-tyrosine kinase.	Leucine rich repeats and immunoglobulin like domains 1.	0.822
ERBB2	LRIG2	ENSSSCP00000018545	ENSSSCP00000071241	Receptor protein-tyrosine kinase.	Leucine rich repeats and immunoglobulin like domains 2.	0.417