Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BRPF1Uncharacterized protein. (1214 aa)    
Predicted Functional Partners:
KAT6A
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.988
KAT6B
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.976
BRPF3
Bromodomain and PHD finger containing 3.
  
0.968
MEAF6
MYST/Esa1 associated factor 6.
   
 0.920
BRD1
Bromodomain containing 1.
  
 
0.914
ING5
Inhibitor of growth family member 5.
    
 0.873
KAT7
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.813
ING4
Inhibitor of growth family member 4.
    
 
 0.747
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.690
ATAD5
ATPase family AAA domain containing 5.
   
 
 0.684
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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