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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
P2RY12Purinergic receptor P2Y12. (339 aa)    
Predicted Functional Partners:
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
     
 0.910
GNAI2
G protein subunit alpha i2.
     
 0.910
GNAI1
Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.
     
 0.910
TREM2
Ig-like domain-containing protein.
      
 0.867
CLEC7A
C-type lectin domain containing 7A.
      
 0.862
P2RY13
Purinergic receptor P2Y13; Belongs to the G-protein coupled receptor 1 family.
   
 
0.841
CSF1R
Colony stimulating factor 1 receptor.
   
  
 0.827
C1QA
Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
   
  
 0.798
OLFML3
Olfactomedin-like protein 3 isoform 1.
      
 0.745
MERTK
MER proto-oncogene, tyrosine kinase.
      
 0.718
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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