node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTFR | IL12A | ENSSSCP00000011703 | ENSSSCP00000012500 | Ciliary neurotrophic factor receptor. | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | 0.741 |
CNTFR | IL12B | ENSSSCP00000011703 | ENSSSCP00000045805 | Ciliary neurotrophic factor receptor. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.671 |
CNTFR | IL27RA | ENSSSCP00000011703 | ENSSSCP00000029613 | Ciliary neurotrophic factor receptor. | Uncharacterized protein. | 0.622 |
CNTFR | IL6ST | ENSSSCP00000011703 | ENSSSCP00000030641 | Ciliary neurotrophic factor receptor. | Interleukin 6 signal transducer. | 0.887 |
CSF3R | IL12A | ENSSSCP00000066684 | ENSSSCP00000012500 | Granulocyte colony-stimulating factor receptor. | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | 0.734 |
CSF3R | IL12B | ENSSSCP00000066684 | ENSSSCP00000045805 | Granulocyte colony-stimulating factor receptor. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.667 |
CSF3R | IL12RB2 | ENSSSCP00000066684 | ENSSSCP00000004110 | Granulocyte colony-stimulating factor receptor. | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.431 |
CSF3R | IL27RA | ENSSSCP00000066684 | ENSSSCP00000029613 | Granulocyte colony-stimulating factor receptor. | Uncharacterized protein. | 0.545 |
CSF3R | IL4R | ENSSSCP00000066684 | ENSSSCP00000008346 | Granulocyte colony-stimulating factor receptor. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.425 |
CSF3R | IL6R | ENSSSCP00000066684 | ENSSSCP00000068722 | Granulocyte colony-stimulating factor receptor. | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. | 0.654 |
IL12A | CNTFR | ENSSSCP00000012500 | ENSSSCP00000011703 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Ciliary neurotrophic factor receptor. | 0.741 |
IL12A | CSF3R | ENSSSCP00000012500 | ENSSSCP00000066684 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Granulocyte colony-stimulating factor receptor. | 0.734 |
IL12A | IL12B | ENSSSCP00000012500 | ENSSSCP00000045805 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.990 |
IL12A | IL12RB1 | ENSSSCP00000012500 | ENSSSCP00000061372 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Interleukin 12 receptor subunit beta 1. | 0.945 |
IL12A | IL12RB2 | ENSSSCP00000012500 | ENSSSCP00000004110 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.929 |
IL12A | IL27RA | ENSSSCP00000012500 | ENSSSCP00000029613 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Uncharacterized protein. | 0.743 |
IL12A | IL4R | ENSSSCP00000012500 | ENSSSCP00000008346 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.733 |
IL12A | IL6R | ENSSSCP00000012500 | ENSSSCP00000068722 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. | 0.756 |
IL12A | IL6ST | ENSSSCP00000012500 | ENSSSCP00000030641 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Interleukin 6 signal transducer. | 0.739 |
IL12A | LEPR | ENSSSCP00000012500 | ENSSSCP00000022838 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. | Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] | 0.761 |