Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
MELTFMelanotransferrin; Belongs to the transferrin family. (737 aa)    
Predicted Functional Partners:
TFRC
Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).
   
 0.824
C2orf78
Chromosome 2 open reading frame 78.
      
 0.765
HPGDS
Hematopoietic prostaglandin D synthase.
   
 
 0.738
THTPA
Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP).
      
 0.700
TFR2
Transferrin receptor 2.
   
 0.700
GIMAP2
GTPase, IMAP family member 2.
   
 
 0.626
ALDH16A1
Aldehyde dehydrogenase 16 family member A1.
   
 0.602
CES5A
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
   
 
 0.574
UABP-2
Uteroferrin-associated basic protein 2.
    
 
 0.524
PRSS37
Putative inactive serine protease 37.
    
 0.524
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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