STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PARP14Poly [ADP-ribose] polymerase. (1784 aa)    
Predicted Functional Partners:
PARP9
Poly(ADP-ribose) polymerase family member 9.
  
 
0.744
PARP16
Poly [ADP-ribose] polymerase.
      
 0.741
GIMAP8
GTPase, IMAP family member 8.
   
  
 0.732
RNF114
E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...]
   
 
 0.717
IFIH1
Interferon induced with helicase C domain 1.
   
 
 0.712
PARP4
Poly [ADP-ribose] polymerase.
    
 
 0.671
DNAJC14
J domain-containing protein.
   
  
 0.667
DTX3L
Deltex E3 ubiquitin ligase 3L.
 
 
 
 0.663
EIF2AK2
Eukaryotic translation initiation factor 2 alpha kinase 2.
   
 
 0.654
PARP8
Poly [ADP-ribose] polymerase.
   
  
 0.653
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.