| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMH | NR0B1 | ENSSSCP00000058593 | ENSSSCP00000012986 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.656 |
| AMH | NR5A1 | ENSSSCP00000058593 | ENSSSCP00000047808 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] | 0.642 |
| AMH | RSPO1 | ENSSSCP00000058593 | ENSSSCP00000047627 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). | R-spondin 1. | 0.500 |
| AMH | WT1 | ENSSSCP00000058593 | ENSSSCP00000019417 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). | Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] | 0.663 |
| ESRRB | NANOG | ENSSSCP00000051043 | ENSSSCP00000056364 | Estrogen related receptor beta. | Homeobox domain-containing protein. | 0.841 |
| ESRRB | NCOR2 | ENSSSCP00000051043 | ENSSSCP00000010425 | Estrogen related receptor beta. | Uncharacterized protein. | 0.749 |
| ESRRB | NR0B1 | ENSSSCP00000051043 | ENSSSCP00000012986 | Estrogen related receptor beta. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.793 |
| ESRRB | PPARG | ENSSSCP00000051043 | ENSSSCP00000012339 | Estrogen related receptor beta. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.474 |
| ESRRB | PRDM14 | ENSSSCP00000051043 | ENSSSCP00000006606 | Estrogen related receptor beta. | PR/SET domain 14. | 0.870 |
| NANOG | ESRRB | ENSSSCP00000056364 | ENSSSCP00000051043 | Homeobox domain-containing protein. | Estrogen related receptor beta. | 0.841 |
| NANOG | NR0B1 | ENSSSCP00000056364 | ENSSSCP00000012986 | Homeobox domain-containing protein. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.774 |
| NANOG | NR5A2 | ENSSSCP00000056364 | ENSSSCP00000053785 | Homeobox domain-containing protein. | Nuclear receptor subfamily 5 group A member 2. | 0.560 |
| NANOG | PPARG | ENSSSCP00000056364 | ENSSSCP00000012339 | Homeobox domain-containing protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.474 |
| NANOG | PRDM14 | ENSSSCP00000056364 | ENSSSCP00000006606 | Homeobox domain-containing protein. | PR/SET domain 14. | 0.767 |
| NCOR2 | ESRRB | ENSSSCP00000010425 | ENSSSCP00000051043 | Uncharacterized protein. | Estrogen related receptor beta. | 0.749 |
| NCOR2 | NR0B1 | ENSSSCP00000010425 | ENSSSCP00000012986 | Uncharacterized protein. | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | 0.678 |
| NCOR2 | NR5A1 | ENSSSCP00000010425 | ENSSSCP00000047808 | Uncharacterized protein. | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidy [...] | 0.538 |
| NCOR2 | NR5A2 | ENSSSCP00000010425 | ENSSSCP00000053785 | Uncharacterized protein. | Nuclear receptor subfamily 5 group A member 2. | 0.538 |
| NCOR2 | PPARG | ENSSSCP00000010425 | ENSSSCP00000012339 | Uncharacterized protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.962 |
| NR0B1 | AMH | ENSSSCP00000012986 | ENSSSCP00000058593 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). | 0.656 |
STRING v12.5 is now available!
