| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATOX1 | ATP7A | ENSSSCP00000050334 | ENSSSCP00000013235 | HMA domain-containing protein. | ATPase copper transporting alpha. | 0.996 |
| ATOX1 | PDZD11 | ENSSSCP00000050334 | ENSSSCP00000029576 | HMA domain-containing protein. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.750 |
| ATP7A | ATOX1 | ENSSSCP00000013235 | ENSSSCP00000050334 | ATPase copper transporting alpha. | HMA domain-containing protein. | 0.996 |
| ATP7A | PDZD11 | ENSSSCP00000013235 | ENSSSCP00000029576 | ATPase copper transporting alpha. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.923 |
| ATP7A | SLC5A6 | ENSSSCP00000013235 | ENSSSCP00000054522 | ATPase copper transporting alpha. | Sodium-dependent multivitamin transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.515 |
| CHD1L | PDZD11 | ENSSSCP00000007145 | ENSSSCP00000029576 | Chromodomain helicase DNA binding protein 1 like. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.599 |
| EIF1AY | PDZD11 | ENSSSCP00000063369 | ENSSSCP00000029576 | Eukaryotic translation initiation factor 1A Y-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.887 |
| ITM2C | MED31 | ENSSSCP00000017233 | ENSSSCP00000025037 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.571 |
| ITM2C | PDZD11 | ENSSSCP00000017233 | ENSSSCP00000029576 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.665 |
| ITM2C | STXBP5 | ENSSSCP00000017233 | ENSSSCP00000053382 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Syntaxin binding protein 5. | 0.523 |
| ITM2C | UNC13B | ENSSSCP00000017233 | ENSSSCP00000067794 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Uncharacterized protein. | 0.514 |
| MED31 | ITM2C | ENSSSCP00000025037 | ENSSSCP00000017233 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.571 |
| MED31 | PDZD11 | ENSSSCP00000025037 | ENSSSCP00000029576 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.676 |
| MED31 | STXBP5 | ENSSSCP00000025037 | ENSSSCP00000053382 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Syntaxin binding protein 5. | 0.575 |
| MED31 | UNC13B | ENSSSCP00000025037 | ENSSSCP00000067794 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Uncharacterized protein. | 0.563 |
| PDZD11 | ATOX1 | ENSSSCP00000029576 | ENSSSCP00000050334 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | HMA domain-containing protein. | 0.750 |
| PDZD11 | ATP7A | ENSSSCP00000029576 | ENSSSCP00000013235 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | ATPase copper transporting alpha. | 0.923 |
| PDZD11 | CHD1L | ENSSSCP00000029576 | ENSSSCP00000007145 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Chromodomain helicase DNA binding protein 1 like. | 0.599 |
| PDZD11 | EIF1AY | ENSSSCP00000029576 | ENSSSCP00000063369 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Eukaryotic translation initiation factor 1A Y-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 0.887 |
| PDZD11 | ITM2C | ENSSSCP00000029576 | ENSSSCP00000017233 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.665 |