STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAMLD1Mastermind-like domain-containing protein 1 isoform 3. (811 aa)    
Predicted Functional Partners:
MTM1
Myotubularin isoform X3.
    
 
 0.863
TRPC5
Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.766
FAM118B
Family with sequence similarity 118 member B.
    
 
 0.659
SRD5A2
3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity).
      
 0.654
C11orf95
Chromosome 11 open reading frame 95.
    
 
 0.610
GON4L
Myb-like domain-containing protein.
    
 
 0.599
NR0B1
Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily.
  
 
 
 0.566
MAML3
Mastermind like transcriptional coactivator 3.
    
 
 0.556
CREBBP
CREB-binding protein isoform a.
    
 0.543
EP300
E1A binding protein p300.
    
 0.543
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.