LOC110257935 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC110257935

Uncharacterized protein. (1836 aa)

Predicted Functional Partners:

ADGRL3

0.650

ADGRL1

0.650

ADGRL2

0.650

RNF7

0.548

MAMDC2

0.521

MMAB

0.521

CCDC137

0.505

MRGPRF

0.499

P2RY8

0.493

GTPBP4

0.473

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRL1	LOC110257935	ENSSSCP00000037086	ENSSSCP00000013641	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.650
ADGRL2	LOC110257935	ENSSSCP00000052051	ENSSSCP00000013641	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.650
ADGRL3	LOC110257935	ENSSSCP00000035950	ENSSSCP00000013641	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.650
CCDC137	GTPBP4	ENSSSCP00000057037	ENSSSCP00000024246	Coiled-coil domain containing 137.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.575
CCDC137	LOC110257935	ENSSSCP00000057037	ENSSSCP00000013641	Coiled-coil domain containing 137.	Uncharacterized protein.	0.505
CCDC137	MMAB	ENSSSCP00000057037	ENSSSCP00000060510	Coiled-coil domain containing 137.	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	0.588
GTPBP4	CCDC137	ENSSSCP00000024246	ENSSSCP00000057037	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	Coiled-coil domain containing 137.	0.575
GTPBP4	LOC110257935	ENSSSCP00000024246	ENSSSCP00000013641	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	Uncharacterized protein.	0.473
GTPBP4	MMAB	ENSSSCP00000024246	ENSSSCP00000060510	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	0.574
LOC110257935	ADGRL1	ENSSSCP00000013641	ENSSSCP00000037086	Uncharacterized protein.	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	0.650
LOC110257935	ADGRL2	ENSSSCP00000013641	ENSSSCP00000052051	Uncharacterized protein.	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	0.650
LOC110257935	ADGRL3	ENSSSCP00000013641	ENSSSCP00000035950	Uncharacterized protein.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.650
LOC110257935	CCDC137	ENSSSCP00000013641	ENSSSCP00000057037	Uncharacterized protein.	Coiled-coil domain containing 137.	0.505
LOC110257935	GTPBP4	ENSSSCP00000013641	ENSSSCP00000024246	Uncharacterized protein.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.473
LOC110257935	MAMDC2	ENSSSCP00000013641	ENSSSCP00000027678	Uncharacterized protein.	MAM domain containing 2.	0.521
LOC110257935	MMAB	ENSSSCP00000013641	ENSSSCP00000060510	Uncharacterized protein.	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	0.521
LOC110257935	MRGPRF	ENSSSCP00000013641	ENSSSCP00000035058	Uncharacterized protein.	Mas-related G-protein coupled receptor member F isoform X1; Belongs to the G-protein coupled receptor 1 family.	0.499
LOC110257935	P2RY8	ENSSSCP00000013641	ENSSSCP00000059770	Uncharacterized protein.	P2Y receptor family member 8; Belongs to the G-protein coupled receptor 1 family.	0.493
LOC110257935	RNF7	ENSSSCP00000013641	ENSSSCP00000026573	Uncharacterized protein.	Ring finger protein 7.	0.548
MAMDC2	LOC110257935	ENSSSCP00000027678	ENSSSCP00000013641	MAM domain containing 2.	Uncharacterized protein.	0.521

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.687

expected number of edges:

18

PPI enrichment p-value:

0.0101

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006865

Amino acid transport

5 of 49

1.86

2.28

9.20e-06

GO:0015803

Branched-chain amino acid transport

2 of 2

2.85

1.37

0.0033

GO:0003333

Amino acid transmembrane transport

2 of 8

2.24

0.91

0.0206

GO:0000160

Phosphorelay signal transduction system

4 of 219

1.11

0.61

0.0315

GO:0006810

Transport

6 of 718

0.77

0.46

0.0315

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

4 of 116

1.38

0.82

0.0148

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

4 of 302

0.97

0.55

0.0314

GO:0005886

Plasma membrane

9 of 1854

0.53

0.37

0.0134

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9153

Mixed, incl. Leucine-binding protein domain, and ANTAR domain

10 of 13

2.73

10.83

1.00e-22

CL:9168

Branched-chain amino acid transport, and Leucine-binding protein domain

5 of 5

2.85

5.17

2.13e-10

CL:9155

ANTAR domain, and Leucine-binding protein domain

3 of 5

2.63

2.37

4.04e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

6 of 380

1.05

0.9

0.00080

map02024

Quorum sensing

5 of 302

1.07

0.83

0.0026

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005561

ANTAR domain

3 of 5

2.63

1.95

0.00026

IPR029016

GAF-like domain superfamily

4 of 34

1.92

1.75

0.00026

IPR003018

GAF domain

3 of 16

2.12

1.47

0.0015

IPR028081

Leucine-binding protein domain

2 of 3

2.67

1.1

0.0101

IPR012074

GAF-ANTAR transcription anti-termination regulator, putative

2 of 3

2.67

1.1

0.0101

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01012

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.

3 of 5

2.63

2.68

1.02e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

4 of 22

2.11

2.58

5.57e-06

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About