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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSFCathepsin F; Belongs to the peptidase C1 family. (474 aa)    
Predicted Functional Partners:
CTSD
Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family.
   
 
 0.820
CLN3
Battenin.
      
 0.731
CLN5
Ceroid-lipofuscinosis neuronal protein 5.
      
 0.722
MFSD8
Major facilitator superfamily domain containing 8.
      
 0.705
CTSB
Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).
  
 
 0.691
CLN6
CLN6 transmembrane ER protein.
   
 
 0.679
CLN8
CLN8 transmembrane ER and ERGIC protein.
   
  
 0.602
GRN
Uncharacterized protein.
   
 
 0.594
TPP1
Tripeptidyl-peptidase 1 preproprotein.
   
 
 0.584
TFEB
Transcription factor EB.
      
 0.569
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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