OTUB1 protein (Sus scrofa) - STRING interaction network

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Score

OTUB1

Ubiquitin thioesterase. (271 aa)

Predicted Functional Partners:

UBE2D1

0.966

RNF128

0.939

TRAF6

0.908

TP53

0.898

FOXM1

0.893

TRAF3

0.878

SLC7A11

0.867

UBE2N

0.859

USP8

0.812

A0A287ARG2_PIG

0.809

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287ARG2_PIG	OTUB1	ENSSSCP00000046445	ENSSSCP00000013872	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin thioesterase.	0.809
A0A287ARG2_PIG	TP53	ENSSSCP00000046445	ENSSSCP00000050664	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.549
A0A287ARG2_PIG	TRAF3	ENSSSCP00000046445	ENSSSCP00000043474	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.638
A0A287ARG2_PIG	TRAF6	ENSSSCP00000046445	ENSSSCP00000034114	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.900
FOXM1	OTUB1	ENSSSCP00000042920	ENSSSCP00000013872	Forkhead box M1.	Ubiquitin thioesterase.	0.893
FOXM1	TP53	ENSSSCP00000042920	ENSSSCP00000050664	Forkhead box M1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.477
OTUB1	A0A287ARG2_PIG	ENSSSCP00000013872	ENSSSCP00000046445	Ubiquitin thioesterase.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.809
OTUB1	FOXM1	ENSSSCP00000013872	ENSSSCP00000042920	Ubiquitin thioesterase.	Forkhead box M1.	0.893
OTUB1	RNF128	ENSSSCP00000013872	ENSSSCP00000013345	Ubiquitin thioesterase.	Ring finger protein 128.	0.939
OTUB1	SLC7A11	ENSSSCP00000013872	ENSSSCP00000027777	Ubiquitin thioesterase.	Solute carrier family 7 member 11.	0.867
OTUB1	TP53	ENSSSCP00000013872	ENSSSCP00000050664	Ubiquitin thioesterase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.898
OTUB1	TRAF3	ENSSSCP00000013872	ENSSSCP00000043474	Ubiquitin thioesterase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.878
OTUB1	TRAF6	ENSSSCP00000013872	ENSSSCP00000034114	Ubiquitin thioesterase.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.908
OTUB1	UBE2D1	ENSSSCP00000013872	ENSSSCP00000038770	Ubiquitin thioesterase.	Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family.	0.966
OTUB1	UBE2N	ENSSSCP00000013872	ENSSSCP00000070241	Ubiquitin thioesterase.	Ubiquitin conjugating enzyme E2 N like (gene/pseudogene).	0.859
OTUB1	USP8	ENSSSCP00000013872	ENSSSCP00000034958	Ubiquitin thioesterase.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.812
RNF128	OTUB1	ENSSSCP00000013345	ENSSSCP00000013872	Ring finger protein 128.	Ubiquitin thioesterase.	0.939
RNF128	TP53	ENSSSCP00000013345	ENSSSCP00000050664	Ring finger protein 128.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.522
RNF128	UBE2D1	ENSSSCP00000013345	ENSSSCP00000038770	Ring finger protein 128.	Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family.	0.701
RNF128	USP8	ENSSSCP00000013345	ENSSSCP00000034958	Ring finger protein 128.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.696