node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F2 | F2R | ENSSSCP00000014081 | ENSSSCP00000035162 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.990 |
F2 | F2RL2 | ENSSSCP00000014081 | ENSSSCP00000049904 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. | 0.988 |
F2 | F2RL3 | ENSSSCP00000014081 | ENSSSCP00000029136 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.981 |
F2 | F5 | ENSSSCP00000014081 | ENSSSCP00000006704 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. | 0.989 |
F2 | FGA | ENSSSCP00000014081 | ENSSSCP00000009602 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] | 0.998 |
F2 | FGB | ENSSSCP00000014081 | ENSSSCP00000009601 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.995 |
F2 | FGG | ENSSSCP00000014081 | ENSSSCP00000024374 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Fibrinogen gamma chain. | 0.993 |
F2 | SERPINC1 | ENSSSCP00000014081 | ENSSSCP00000067774 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | SERPIN domain-containing protein; Belongs to the serpin family. | 0.999 |
F2 | SERPIND1 | ENSSSCP00000014081 | ENSSSCP00000010766 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Serpin family D member 1; Belongs to the serpin family. | 0.997 |
F2 | THBD | ENSSSCP00000014081 | ENSSSCP00000060247 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Uncharacterized protein. | 0.995 |
F2R | F2 | ENSSSCP00000035162 | ENSSSCP00000014081 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.990 |
F2R | F2RL2 | ENSSSCP00000035162 | ENSSSCP00000049904 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. | 0.453 |
F2R | F2RL3 | ENSSSCP00000035162 | ENSSSCP00000029136 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.908 |
F2R | FGG | ENSSSCP00000035162 | ENSSSCP00000024374 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Fibrinogen gamma chain. | 0.501 |
F2R | THBD | ENSSSCP00000035162 | ENSSSCP00000060247 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.573 |
F2RL2 | F2 | ENSSSCP00000049904 | ENSSSCP00000014081 | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.988 |
F2RL2 | F2R | ENSSSCP00000049904 | ENSSSCP00000035162 | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.453 |
F2RL2 | F2RL3 | ENSSSCP00000049904 | ENSSSCP00000029136 | Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.910 |
F2RL3 | F2 | ENSSSCP00000029136 | ENSSSCP00000014081 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.981 |
F2RL3 | F2R | ENSSSCP00000029136 | ENSSSCP00000035162 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.908 |