Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)    
Predicted Functional Partners:
CHRM2
Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
  
  
0.983
GNG2
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
    
 0.954
GNB4
G protein subunit beta 4.
    
 0.950
GNB2
G protein subunit beta 2.
    
 0.947
GNAI2
G protein subunit alpha i2.
    
 0.942
GNAI1
Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.
    
 0.942
GNAO1
Guanine nucleotide-binding protein G(O) subunit alpha isoform b.
    
 0.939
GNB5
G protein subunit beta 5.
    
 0.933
GNB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1.
    
 0.931
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
    
 0.926
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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