node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC8 | KCNJ11 | ENSSSCP00000014217 | ENSSSCP00000061805 | ATP binding cassette subfamily C member 8. | Potassium voltage-gated channel subfamily J member 11. | 0.999 |
ABCC8 | KCNJ8 | ENSSSCP00000014217 | ENSSSCP00000052629 | ATP binding cassette subfamily C member 8. | Potassium voltage-gated channel subfamily J member 8. | 0.955 |
ABCC8 | PCSK1 | ENSSSCP00000014217 | ENSSSCP00000015068 | ATP binding cassette subfamily C member 8. | P/Homo B domain-containing protein; Belongs to the peptidase S8 family. | 0.724 |
ABCC8 | PRKACA | ENSSSCP00000014217 | ENSSSCP00000035101 | ATP binding cassette subfamily C member 8. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.907 |
ABCC8 | PRKACB | ENSSSCP00000014217 | ENSSSCP00000058922 | ATP binding cassette subfamily C member 8. | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.907 |
ABCC8 | RAPGEF3 | ENSSSCP00000014217 | ENSSSCP00000020148 | ATP binding cassette subfamily C member 8. | Rap guanine nucleotide exchange factor 3 isoform a. | 0.770 |
ABCC8 | RAPGEF4 | ENSSSCP00000014217 | ENSSSCP00000016912 | ATP binding cassette subfamily C member 8. | Rap guanine nucleotide exchange factor 4. | 0.854 |
ABCC8 | SLC2A2 | ENSSSCP00000014217 | ENSSSCP00000060505 | ATP binding cassette subfamily C member 8. | Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate; Belongs to the major fac [...] | 0.678 |
ABCC8 | SLC30A8 | ENSSSCP00000014217 | ENSSSCP00000044079 | ATP binding cassette subfamily C member 8. | Solute carrier family 30 member 8. | 0.811 |
ABCC8 | SNED1 | ENSSSCP00000014217 | ENSSSCP00000060289 | ATP binding cassette subfamily C member 8. | Sushi, nidogen and EGF like domains 1. | 0.625 |
KCNJ11 | ABCC8 | ENSSSCP00000061805 | ENSSSCP00000014217 | Potassium voltage-gated channel subfamily J member 11. | ATP binding cassette subfamily C member 8. | 0.999 |
KCNJ11 | KCNJ8 | ENSSSCP00000061805 | ENSSSCP00000052629 | Potassium voltage-gated channel subfamily J member 11. | Potassium voltage-gated channel subfamily J member 8. | 0.513 |
KCNJ11 | PCSK1 | ENSSSCP00000061805 | ENSSSCP00000015068 | Potassium voltage-gated channel subfamily J member 11. | P/Homo B domain-containing protein; Belongs to the peptidase S8 family. | 0.567 |
KCNJ11 | RAPGEF3 | ENSSSCP00000061805 | ENSSSCP00000020148 | Potassium voltage-gated channel subfamily J member 11. | Rap guanine nucleotide exchange factor 3 isoform a. | 0.754 |
KCNJ11 | RAPGEF4 | ENSSSCP00000061805 | ENSSSCP00000016912 | Potassium voltage-gated channel subfamily J member 11. | Rap guanine nucleotide exchange factor 4. | 0.772 |
KCNJ11 | SLC2A2 | ENSSSCP00000061805 | ENSSSCP00000060505 | Potassium voltage-gated channel subfamily J member 11. | Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate; Belongs to the major fac [...] | 0.604 |
KCNJ11 | SLC30A8 | ENSSSCP00000061805 | ENSSSCP00000044079 | Potassium voltage-gated channel subfamily J member 11. | Solute carrier family 30 member 8. | 0.624 |
KCNJ8 | ABCC8 | ENSSSCP00000052629 | ENSSSCP00000014217 | Potassium voltage-gated channel subfamily J member 8. | ATP binding cassette subfamily C member 8. | 0.955 |
KCNJ8 | KCNJ11 | ENSSSCP00000052629 | ENSSSCP00000061805 | Potassium voltage-gated channel subfamily J member 8. | Potassium voltage-gated channel subfamily J member 11. | 0.513 |
PCSK1 | ABCC8 | ENSSSCP00000015068 | ENSSSCP00000014217 | P/Homo B domain-containing protein; Belongs to the peptidase S8 family. | ATP binding cassette subfamily C member 8. | 0.724 |