node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADM | CALCB-2 | ENSSSCP00000014253 | ENSSSCP00000040016 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | 0.929 |
ADM | CALCR | ENSSSCP00000014253 | ENSSSCP00000057815 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. | 0.777 |
ADM | CALCRL | ENSSSCP00000014253 | ENSSSCP00000039864 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). | 0.998 |
ADM | CRSP-2 | ENSSSCP00000014253 | ENSSSCP00000014228 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Calcitonin receptor-stimulating peptide 2; Belongs to the calcitonin family. | 0.927 |
ADM | CRSP3 | ENSSSCP00000014253 | ENSSSCP00000014226 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Calcitonin receptor-stimulating peptide 3; Belongs to the calcitonin family. | 0.927 |
ADM | IAPP | ENSSSCP00000014253 | ENSSSCP00000046960 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. | 0.969 |
ADM | RAMP1 | ENSSSCP00000014253 | ENSSSCP00000017303 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). | 0.985 |
ADM | RAMP2 | ENSSSCP00000014253 | ENSSSCP00000018424 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Receptor activity-modifying protein 2. | 0.989 |
ADM | RAMP3 | ENSSSCP00000014253 | ENSSSCP00000046054 | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). | 0.994 |
CALCB-2 | ADM | ENSSSCP00000040016 | ENSSSCP00000014253 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | 0.929 |
CALCB-2 | CALCR | ENSSSCP00000040016 | ENSSSCP00000057815 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. | 0.863 |
CALCB-2 | CALCRL | ENSSSCP00000040016 | ENSSSCP00000039864 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). | 0.975 |
CALCB-2 | CRSP-2 | ENSSSCP00000040016 | ENSSSCP00000014228 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Calcitonin receptor-stimulating peptide 2; Belongs to the calcitonin family. | 0.961 |
CALCB-2 | CRSP3 | ENSSSCP00000040016 | ENSSSCP00000014226 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Calcitonin receptor-stimulating peptide 3; Belongs to the calcitonin family. | 0.948 |
CALCB-2 | IAPP | ENSSSCP00000040016 | ENSSSCP00000046960 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. | 0.939 |
CALCB-2 | RAMP1 | ENSSSCP00000040016 | ENSSSCP00000017303 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). | 0.964 |
CALCB-2 | RAMP2 | ENSSSCP00000040016 | ENSSSCP00000018424 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Receptor activity-modifying protein 2. | 0.966 |
CALCB-2 | RAMP3 | ENSSSCP00000040016 | ENSSSCP00000046054 | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). | 0.939 |
CALCR | ADM | ENSSSCP00000057815 | ENSSSCP00000014253 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. | Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. | 0.777 |
CALCR | CALCB-2 | ENSSSCP00000057815 | ENSSSCP00000040016 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells; Belongs to the G-protein coupled receptor 2 family. | Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. | 0.863 |