STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD209CD209 antigen isoform X1. (240 aa)    
Predicted Functional Partners:
ICAM3
ICAM_N domain-containing protein.
   
 
 0.973
LSP1
Lymphocyte specific protein 1.
    
 0.938
KSR1
Kinase suppressor of ras 1.
    
 0.907
RHOA
Transforming protein RhoA isoform 1.
   
  0.905
ARHGEF12
Rho guanine nucleotide exchange factor 12.
     
 0.903
PLK3
Serine/threonine-protein kinase PLK.
    
  0.900
CD151
Tetraspanin.
      
 0.856
CD163
Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...]
   
 
 0.814
AXL
Uncharacterized protein.
    
 
 0.761
CD86
T-lymphocyte activation antigen CD86 isoform 1.
   
  
 0.741
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.