Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PRKCSHGlucosidase 2 subunit beta isoform X1. (537 aa)    
Predicted Functional Partners:
GANAB
Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
   
 0.999
CANX
Calnexin.
   
 0.962
GNPTAB
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta.
    
 0.926
SEC63
SEC63 homolog, protein translocation regulator.
   
  
 0.897
CALR
Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family.
   
 
 0.855
ALG5
Glyco_trans_2-like domain-containing protein.
   
  
 0.791
CDH1
Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.
   
 
  0.778
ALG9
Mannosyltransferase.
      
 0.766
HSP90B1
Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family.
   
 
 0.762
ALG8
Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family.
      
 0.737
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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