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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ICAM4ICAM_N domain-containing protein. (272 aa)    
Predicted Functional Partners:
ITGB2
Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...]
     
 0.728
FERD3L
Fer3 like bHLH transcription factor.
   
  
 0.662
ERMAP
Erythroblast membrane associated protein (Scianna blood group).
   
  
 0.628
ITGAL
Integrin subunit alpha L; Belongs to the integrin alpha chain family.
     
 0.614
A4GALT
Lactosylceramide 4-alpha-galactosyltransferase isoform X1.
      
 0.578
NPTN
Neuroplastin.
      
 0.570
RHCE
Rh protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
   
  
 0.569
FUT7
Alpha-(1,3)-fucosyltransferase 7.
      
 0.547
KEL
Kell metallo-endopeptidase (Kell blood group).
   
  
 0.532
GSE1
Gse1 coiled-coil protein.
      
 0.517
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.