Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FCHO1FCH domain only 1. (969 aa)    
Predicted Functional Partners:
EPS15
Epidermal growth factor receptor pathway substrate 15.
   
 0.968
ITSN2
Intersectin 2.
   
 0.951
ITSN1
Intersectin 1.
   
 0.932
SNX9
Sorting nexin 9.
    
 0.927
AMPH
Uncharacterized protein.
   
 0.910
EPS15L1
Epidermal growth factor receptor pathway substrate 15 like 1.
   
 
 0.898
AP2B1
AP complex subunit beta.
   
 0.894
DAB2
DAB adaptor protein 2.
   
 0.866
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
   
 0.856
NECAP2
Adaptin ear-binding coat-associated protein 2 isoform 1.
    
 0.853
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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