FLT4 protein (Sus scrofa) - STRING interaction network

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FLT4

Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)

Predicted Functional Partners:

VEGFC

0.986

VEGFD

0.914

PTK2

0.914

VEGFB

0.904

ANGPT2

0.876

GRB2

0.842

PDGFC

0.835

ANGPT4

0.802

PDGFA

0.790

SHC1

0.789

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT2	ANGPT4	ENSSSCP00000067734	ENSSSCP00000007666	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Angiopoietin 4.	0.920
ANGPT2	FLT4	ENSSSCP00000067734	ENSSSCP00000014892	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.876
ANGPT2	PDGFA	ENSSSCP00000067734	ENSSSCP00000008054	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.	0.400
ANGPT2	VEGFB	ENSSSCP00000067734	ENSSSCP00000013864	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.570
ANGPT2	VEGFC	ENSSSCP00000067734	ENSSSCP00000016710	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.686
ANGPT2	VEGFD	ENSSSCP00000067734	ENSSSCP00000012918	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family.	0.513
ANGPT4	ANGPT2	ENSSSCP00000007666	ENSSSCP00000067734	Angiopoietin 4.	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	0.920
ANGPT4	FLT4	ENSSSCP00000007666	ENSSSCP00000014892	Angiopoietin 4.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.802
ANGPT4	VEGFC	ENSSSCP00000007666	ENSSSCP00000016710	Angiopoietin 4.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.453
FLT4	ANGPT2	ENSSSCP00000014892	ENSSSCP00000067734	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	0.876
FLT4	ANGPT4	ENSSSCP00000014892	ENSSSCP00000007666	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Angiopoietin 4.	0.802
FLT4	GRB2	ENSSSCP00000014892	ENSSSCP00000018229	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Growth factor receptor-bound protein 2 isoform 1.	0.842
FLT4	PDGFA	ENSSSCP00000014892	ENSSSCP00000008054	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.	0.790
FLT4	PDGFC	ENSSSCP00000014892	ENSSSCP00000024797	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.835
FLT4	PTK2	ENSSSCP00000014892	ENSSSCP00000057598	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.914
FLT4	SHC1	ENSSSCP00000014892	ENSSSCP00000028571	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	SHC adaptor protein 1.	0.789
FLT4	VEGFB	ENSSSCP00000014892	ENSSSCP00000013864	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.904
FLT4	VEGFC	ENSSSCP00000014892	ENSSSCP00000016710	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.986
FLT4	VEGFD	ENSSSCP00000014892	ENSSSCP00000012918	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family.	0.914
GRB2	FLT4	ENSSSCP00000018229	ENSSSCP00000014892	Growth factor receptor-bound protein 2 isoform 1.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.842