Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SNCBBeta-synuclein; Belongs to the synuclein family. (183 aa)    
Predicted Functional Partners:
SNCA
Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]
   
 
 0.944
SNCG
Gamma-synuclein; Belongs to the synuclein family.
   
 
 0.770
LYPD6B
LY6/PLAUR domain containing 6B.
   
  
 0.648
CPLX1
Complexin 1.
   
  
 0.600
SNCAIP
Uncharacterized protein.
    
 
 0.589
UNC5A
Netrin receptor UNC5A isoform X3.
   
  
 0.571
NRSN2
Neurensin 2.
   
  
 0.570
INA
Internexin neuronal intermediate filament protein alpha; Belongs to the intermediate filament family.
   
  
 0.525
SLC30A9
Uncharacterized protein.
      
 0.470
PLP1
Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity); Belongs to the myelin proteolipid protein family.
   
  
 0.469
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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