Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)    
Predicted Functional Partners:
CRH
Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
   
 0.984
CRHR1
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.751
CRHR2
Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.720
UCN2
Urocortin 2.
      
 0.640
MCT7
Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily.
      
 0.622
SELRC1
Uncharacterized protein.
    
   0.598
TNIP1
TNFAIP3 interacting protein 1.
    
   0.566
FKBP14
Peptidylprolyl isomerase.
   
  
 0.531
PHLDB3
Pleckstrin homology like domain family B member 3.
    
   0.525
S100Z
Protein S100; Belongs to the S-100 family.
      
 0.470
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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