node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC8 | CHGB | ENSSSCP00000014217 | ENSSSCP00000034002 | ATP binding cassette subfamily C member 8. | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.577 |
ABCC8 | CPE | ENSSSCP00000014217 | ENSSSCP00000009445 | ATP binding cassette subfamily C member 8. | Carboxypeptidase E. | 0.452 |
ABCC8 | GCG | ENSSSCP00000014217 | ENSSSCP00000016844 | ATP binding cassette subfamily C member 8. | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | 0.494 |
ABCC8 | GCK | ENSSSCP00000014217 | ENSSSCP00000048940 | ATP binding cassette subfamily C member 8. | Glucokinase. | 0.581 |
ABCC8 | GLP1R | ENSSSCP00000014217 | ENSSSCP00000069601 | ATP binding cassette subfamily C member 8. | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | 0.531 |
ABCC8 | INS | ENSSSCP00000014217 | ENSSSCP00000044635 | ATP binding cassette subfamily C member 8. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.511 |
ABCC8 | PCSK1 | ENSSSCP00000014217 | ENSSSCP00000015068 | ATP binding cassette subfamily C member 8. | P/Homo B domain-containing protein; Belongs to the peptidase S8 family. | 0.724 |
ABCC8 | SLC30A8 | ENSSSCP00000014217 | ENSSSCP00000044079 | ATP binding cassette subfamily C member 8. | Solute carrier family 30 member 8. | 0.811 |
CHGB | ABCC8 | ENSSSCP00000034002 | ENSSSCP00000014217 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | ATP binding cassette subfamily C member 8. | 0.577 |
CHGB | CPE | ENSSSCP00000034002 | ENSSSCP00000009445 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Carboxypeptidase E. | 0.518 |
CHGB | INS | ENSSSCP00000034002 | ENSSSCP00000044635 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.471 |
CHGB | PCSK1 | ENSSSCP00000034002 | ENSSSCP00000015068 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | P/Homo B domain-containing protein; Belongs to the peptidase S8 family. | 0.701 |
CPE | ABCC8 | ENSSSCP00000009445 | ENSSSCP00000014217 | Carboxypeptidase E. | ATP binding cassette subfamily C member 8. | 0.452 |
CPE | CHGB | ENSSSCP00000009445 | ENSSSCP00000034002 | Carboxypeptidase E. | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.518 |
CPE | INS | ENSSSCP00000009445 | ENSSSCP00000044635 | Carboxypeptidase E. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.607 |
CPE | PCSK1 | ENSSSCP00000009445 | ENSSSCP00000015068 | Carboxypeptidase E. | P/Homo B domain-containing protein; Belongs to the peptidase S8 family. | 0.704 |
CPE | POMC | ENSSSCP00000009445 | ENSSSCP00000024582 | Carboxypeptidase E. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.483 |
GCG | ABCC8 | ENSSSCP00000016844 | ENSSSCP00000014217 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | ATP binding cassette subfamily C member 8. | 0.494 |
GCG | GCK | ENSSSCP00000016844 | ENSSSCP00000048940 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Glucokinase. | 0.799 |
GCG | GHRL | ENSSSCP00000016844 | ENSSSCP00000012327 | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.973 |