LOX protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS3	LOX	ENSSSCP00000065940	ENSSSCP00000015138	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.673
ALOX15	LOX	ENSSSCP00000030128	ENSSSCP00000015138	Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...]	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.685
COL1A1	ELN	ENSSSCP00000066291	ENSSSCP00000048714	Collagen type I alpha 1 chain.	Elastin.	0.670
COL1A1	FBN1	ENSSSCP00000066291	ENSSSCP00000005017	Collagen type I alpha 1 chain.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.818
COL1A1	FN1	ENSSSCP00000066291	ENSSSCP00000017132	Collagen type I alpha 1 chain.	Fibronectin 1.	0.894
COL1A1	LOX	ENSSSCP00000066291	ENSSSCP00000015138	Collagen type I alpha 1 chain.	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.672
COL1A1	SERPINH1	ENSSSCP00000066291	ENSSSCP00000034354	Collagen type I alpha 1 chain.	SERPIN domain-containing protein; Belongs to the serpin family.	0.662
EFEMP2	ELN	ENSSSCP00000056455	ENSSSCP00000048714	EGF containing fibulin extracellular matrix protein 2.	Elastin.	0.681
EFEMP2	FBN1	ENSSSCP00000056455	ENSSSCP00000005017	EGF containing fibulin extracellular matrix protein 2.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.414
EFEMP2	LOX	ENSSSCP00000056455	ENSSSCP00000015138	EGF containing fibulin extracellular matrix protein 2.	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.841
ELN	COL1A1	ENSSSCP00000048714	ENSSSCP00000066291	Elastin.	Collagen type I alpha 1 chain.	0.670
ELN	EFEMP2	ENSSSCP00000048714	ENSSSCP00000056455	Elastin.	EGF containing fibulin extracellular matrix protein 2.	0.681
ELN	FBLN5	ENSSSCP00000048714	ENSSSCP00000002645	Elastin.	Fibulin-5 isoform X2.	0.930
ELN	FBN1	ENSSSCP00000048714	ENSSSCP00000005017	Elastin.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.949
ELN	FN1	ENSSSCP00000048714	ENSSSCP00000017132	Elastin.	Fibronectin 1.	0.696
ELN	LOX	ENSSSCP00000048714	ENSSSCP00000015138	Elastin.	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.977
FBLN5	ELN	ENSSSCP00000002645	ENSSSCP00000048714	Fibulin-5 isoform X2.	Elastin.	0.930
FBLN5	LOX	ENSSSCP00000002645	ENSSSCP00000015138	Fibulin-5 isoform X2.	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.825
FBN1	COL1A1	ENSSSCP00000005017	ENSSSCP00000066291	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	Collagen type I alpha 1 chain.	0.818
FBN1	EFEMP2	ENSSSCP00000005017	ENSSSCP00000056455	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	EGF containing fibulin extracellular matrix protein 2.	0.414