STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRDM6PR/SET domain 6. (589 aa)    
Predicted Functional Partners:
SMYD2
N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily.
    
 
 0.691
PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.
     
 0.672
KMT5C
Lysine methyltransferase 5C.
      
 0.668
PRDM14
PR/SET domain 14.
    
 
0.659
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.654
PLOD3
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3.
     
  0.650
PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.
     
  0.650
CBFA2T2
CBFA2/RUNX1 partner transcriptional co-repressor 2.
    
 
 0.581
LRRC61
Dimer_Tnp_hAT domain-containing protein.
    
 
 0.577
CEBPG
CCAAT enhancer binding protein gamma.
    
 
 0.569
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.