STRINGSTRING
IL-5 protein (Sus scrofa) - STRING interaction network
"IL-5" - Interleukin-5 in Sus scrofa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL-5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells (134 aa)    
Predicted Functional Partners:
IL2
Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells (154 aa)
         
  0.993
IL5RA
Interleukin 5 receptor, alpha (423 aa)
       
  0.992
CSF2
Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes (144 aa)
         
  0.986
IL2RA
Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells (251 aa)
         
  0.954
CSF2RB
Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (898 aa)
       
  0.947
JAK2
Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, [...] (1095 aa)
         
  0.931
CSF2RA
Uncharacterized protein; Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (353 aa)
         
  0.926
JAK1
Janus kinase 1 (330 aa)
         
  0.925
JAK3
Janus kinase 3 (1104 aa)
         
  0.923
IL2RB
Interleukin 2 receptor subunit beta (555 aa)
         
  0.915
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
Server load: low (23%) [HD]