node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FKBP4 | FKBP5 | ENSSSCP00000065998 | ENSSSCP00000033815 | Peptidylprolyl isomerase. | Peptidylprolyl isomerase. | 0.924 |
FKBP4 | HSP90AA1 | ENSSSCP00000065998 | ENSSSCP00000046159 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.850 |
FKBP4 | HSP90AB1 | ENSSSCP00000065998 | ENSSSCP00000032023 | Peptidylprolyl isomerase. | Heat shock protein 90 alpha family class B member 1. | 0.850 |
FKBP4 | NR3C1 | ENSSSCP00000065998 | ENSSSCP00000046572 | Peptidylprolyl isomerase. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.924 |
FKBP4 | NR3C2 | ENSSSCP00000065998 | ENSSSCP00000029662 | Peptidylprolyl isomerase. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.901 |
FKBP4 | PTGES3 | ENSSSCP00000065998 | ENSSSCP00000000433 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3. | 0.931 |
FKBP4 | STIP1 | ENSSSCP00000065998 | ENSSSCP00000025642 | Peptidylprolyl isomerase. | Stress induced phosphoprotein 1. | 0.793 |
FKBP5 | FKBP4 | ENSSSCP00000033815 | ENSSSCP00000065998 | Peptidylprolyl isomerase. | Peptidylprolyl isomerase. | 0.924 |
FKBP5 | HSP90AA1 | ENSSSCP00000033815 | ENSSSCP00000046159 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.890 |
FKBP5 | HSP90AB1 | ENSSSCP00000033815 | ENSSSCP00000032023 | Peptidylprolyl isomerase. | Heat shock protein 90 alpha family class B member 1. | 0.903 |
FKBP5 | NCOA2 | ENSSSCP00000033815 | ENSSSCP00000042311 | Peptidylprolyl isomerase. | Nuclear receptor coactivator. | 0.484 |
FKBP5 | NR3C1 | ENSSSCP00000033815 | ENSSSCP00000046572 | Peptidylprolyl isomerase. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.948 |
FKBP5 | NR3C2 | ENSSSCP00000033815 | ENSSSCP00000029662 | Peptidylprolyl isomerase. | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.795 |
FKBP5 | PTGES3 | ENSSSCP00000033815 | ENSSSCP00000000433 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3. | 0.946 |
FKBP5 | STIP1 | ENSSSCP00000033815 | ENSSSCP00000025642 | Peptidylprolyl isomerase. | Stress induced phosphoprotein 1. | 0.769 |
HSP90AA1 | FKBP4 | ENSSSCP00000046159 | ENSSSCP00000065998 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Peptidylprolyl isomerase. | 0.850 |
HSP90AA1 | FKBP5 | ENSSSCP00000046159 | ENSSSCP00000033815 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Peptidylprolyl isomerase. | 0.890 |
HSP90AA1 | HSP90AB1 | ENSSSCP00000046159 | ENSSSCP00000032023 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock protein 90 alpha family class B member 1. | 0.965 |
HSP90AA1 | NR3C1 | ENSSSCP00000046159 | ENSSSCP00000046572 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.905 |
HSP90AA1 | NR3C2 | ENSSSCP00000046159 | ENSSSCP00000029662 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). | 0.648 |