LOC100516631 protein (Sus scrofa) - STRING interaction network

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Score

LOC100516631

G_PROTEIN_RECEP_F1_2 domain-containing protein. (317 aa)

Predicted Functional Partners:

GNG13

0.609

GNAL

0.605

GRK3

0.601

PRKACA

0.579

GNB4

0.579

PRKACB

0.579

GRK2

0.560

GNB2

0.483

GNAS

0.483

ARRB1

0.450

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	GNB2	ENSSSCP00000033134	ENSSSCP00000008190	Arrestin beta 1.	G protein subunit beta 2.	0.464
ARRB1	GNB4	ENSSSCP00000033134	ENSSSCP00000036910	Arrestin beta 1.	G protein subunit beta 4.	0.464
ARRB1	GRK2	ENSSSCP00000033134	ENSSSCP00000072808	Arrestin beta 1.	G protein-coupled receptor kinase 2.	0.985
ARRB1	GRK3	ENSSSCP00000033134	ENSSSCP00000063949	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.982
ARRB1	LOC100516631	ENSSSCP00000033134	ENSSSCP00000015693	Arrestin beta 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.450
ARRB1	PRKACA	ENSSSCP00000033134	ENSSSCP00000035101	Arrestin beta 1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.585
ARRB1	PRKACB	ENSSSCP00000033134	ENSSSCP00000058922	Arrestin beta 1.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.585
GNAL	GNAS	ENSSSCP00000026869	ENSSSCP00000029311	G protein subunit alpha L.	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	0.919
GNAL	GNB2	ENSSSCP00000026869	ENSSSCP00000008190	G protein subunit alpha L.	G protein subunit beta 2.	0.909
GNAL	GNB4	ENSSSCP00000026869	ENSSSCP00000036910	G protein subunit alpha L.	G protein subunit beta 4.	0.974
GNAL	GNG13	ENSSSCP00000026869	ENSSSCP00000008555	G protein subunit alpha L.	G protein subunit gamma 13.	0.984
GNAL	LOC100516631	ENSSSCP00000026869	ENSSSCP00000015693	G protein subunit alpha L.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.605
GNAS	GNAL	ENSSSCP00000029311	ENSSSCP00000026869	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	G protein subunit alpha L.	0.919
GNAS	GNB2	ENSSSCP00000029311	ENSSSCP00000008190	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	G protein subunit beta 2.	0.997
GNAS	GNB4	ENSSSCP00000029311	ENSSSCP00000036910	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	G protein subunit beta 4.	0.998
GNAS	GNG13	ENSSSCP00000029311	ENSSSCP00000008555	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	G protein subunit gamma 13.	0.996
GNAS	LOC100516631	ENSSSCP00000029311	ENSSSCP00000015693	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.483
GNB2	ARRB1	ENSSSCP00000008190	ENSSSCP00000033134	G protein subunit beta 2.	Arrestin beta 1.	0.464
GNB2	GNAL	ENSSSCP00000008190	ENSSSCP00000026869	G protein subunit beta 2.	G protein subunit alpha L.	0.909
GNB2	GNAS	ENSSSCP00000008190	ENSSSCP00000029311	G protein subunit beta 2.	Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.	0.997