MMP8 protein (Sus scrofa) - STRING interaction network

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Score

MMP8

Matrix metallopeptidase 8. (468 aa)

Predicted Functional Partners:

MMP9

0.929

TIMP1

0.901

TIMP2

0.798

TIMP3

0.767

TIMP4

0.748

ELANE

0.745

NFKB1

0.724

NFKB2

0.718

A2M

0.637

MMP20

0.630

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2M	MMP20	ENSSSCP00000000701	ENSSSCP00000015906	Alpha-2-macroglobulin.	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	0.584
A2M	MMP8	ENSSSCP00000000701	ENSSSCP00000015908	Alpha-2-macroglobulin.	Matrix metallopeptidase 8.	0.637
A2M	MMP9	ENSSSCP00000000701	ENSSSCP00000049256	Alpha-2-macroglobulin.	Matrix metalloproteinase-9.	0.705
A2M	TIMP1	ENSSSCP00000000701	ENSSSCP00000013066	Alpha-2-macroglobulin.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.582
ELANE	MMP8	ENSSSCP00000024494	ENSSSCP00000015908	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	Matrix metallopeptidase 8.	0.745
ELANE	MMP9	ENSSSCP00000024494	ENSSSCP00000049256	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	Matrix metalloproteinase-9.	0.584
MMP20	A2M	ENSSSCP00000015906	ENSSSCP00000000701	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Alpha-2-macroglobulin.	0.584
MMP20	MMP8	ENSSSCP00000015906	ENSSSCP00000015908	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Matrix metallopeptidase 8.	0.630
MMP20	MMP9	ENSSSCP00000015906	ENSSSCP00000049256	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Matrix metalloproteinase-9.	0.795
MMP20	NFKB1	ENSSSCP00000015906	ENSSSCP00000048015	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Uncharacterized protein.	0.581
MMP20	NFKB2	ENSSSCP00000015906	ENSSSCP00000011271	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Nuclear factor NF-kappa-B p100 subunit isoform X1.	0.510
MMP20	TIMP1	ENSSSCP00000015906	ENSSSCP00000013066	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.548
MMP20	TIMP2	ENSSSCP00000015906	ENSSSCP00000067249	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	Uncharacterized protein.	0.607
MMP20	TIMP3	ENSSSCP00000015906	ENSSSCP00000037032	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	TIMP metallopeptidase inhibitor 3.	0.773
MMP20	TIMP4	ENSSSCP00000015906	ENSSSCP00000049865	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	TIMP metallopeptidase inhibitor 4.	0.407
MMP8	A2M	ENSSSCP00000015908	ENSSSCP00000000701	Matrix metallopeptidase 8.	Alpha-2-macroglobulin.	0.637
MMP8	ELANE	ENSSSCP00000015908	ENSSSCP00000024494	Matrix metallopeptidase 8.	Elastase, neutrophil expressed; Belongs to the peptidase S1 family.	0.745
MMP8	MMP20	ENSSSCP00000015908	ENSSSCP00000015906	Matrix metallopeptidase 8.	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	0.630
MMP8	MMP9	ENSSSCP00000015908	ENSSSCP00000049256	Matrix metallopeptidase 8.	Matrix metalloproteinase-9.	0.929
MMP8	NFKB1	ENSSSCP00000015908	ENSSSCP00000048015	Matrix metallopeptidase 8.	Uncharacterized protein.	0.724