MMP1 protein (Sus scrofa) - STRING interaction network

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Score

MMP1

Stromelysin-1 preproprotein. (477 aa)

Predicted Functional Partners:

MMP9

0.917

TIMP3

0.880

SPP1

0.870

TIMP1

0.860

ACAN

0.852

MMP13

0.850

MMP7

0.847

TIMP2

0.842

ADAMTS5

0.813

ADAMTS4

0.799

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS4	ENSSSCP00000052661	ENSSSCP00000006778	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.963
ACAN	ADAMTS5	ENSSSCP00000052661	ENSSSCP00000012809	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.963
ACAN	MMP1	ENSSSCP00000052661	ENSSSCP00000015910	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Stromelysin-1 preproprotein.	0.852
ACAN	MMP13	ENSSSCP00000052661	ENSSSCP00000015912	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrix metallopeptidase 13.	0.937
ACAN	MMP9	ENSSSCP00000052661	ENSSSCP00000049256	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrix metalloproteinase-9.	0.636
ACAN	SPP1	ENSSSCP00000052661	ENSSSCP00000009825	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family.	0.641
ACAN	TIMP1	ENSSSCP00000052661	ENSSSCP00000013066	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.547
ACAN	TIMP2	ENSSSCP00000052661	ENSSSCP00000067249	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Uncharacterized protein.	0.450
ACAN	TIMP3	ENSSSCP00000052661	ENSSSCP00000037032	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	TIMP metallopeptidase inhibitor 3.	0.559
ADAMTS4	ACAN	ENSSSCP00000006778	ENSSSCP00000052661	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.963
ADAMTS4	MMP1	ENSSSCP00000006778	ENSSSCP00000015910	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Stromelysin-1 preproprotein.	0.799
ADAMTS4	MMP13	ENSSSCP00000006778	ENSSSCP00000015912	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Matrix metallopeptidase 13.	0.883
ADAMTS4	MMP9	ENSSSCP00000006778	ENSSSCP00000049256	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Matrix metalloproteinase-9.	0.586
ADAMTS4	TIMP1	ENSSSCP00000006778	ENSSSCP00000013066	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.542
ADAMTS4	TIMP3	ENSSSCP00000006778	ENSSSCP00000037032	ADAM metallopeptidase with thrombospondin type 1 motif 4.	TIMP metallopeptidase inhibitor 3.	0.668
ADAMTS5	ACAN	ENSSSCP00000012809	ENSSSCP00000052661	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.963
ADAMTS5	MMP1	ENSSSCP00000012809	ENSSSCP00000015910	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Stromelysin-1 preproprotein.	0.813
ADAMTS5	MMP13	ENSSSCP00000012809	ENSSSCP00000015912	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Matrix metallopeptidase 13.	0.926
ADAMTS5	MMP9	ENSSSCP00000012809	ENSSSCP00000049256	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Matrix metalloproteinase-9.	0.580
ADAMTS5	TIMP1	ENSSSCP00000012809	ENSSSCP00000013066	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.468