| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGF | FLT1 | ENSSSCP00000028117 | ENSSSCP00000062931 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.917 |
| EGF | FLT3 | ENSSSCP00000028117 | ENSSSCP00000028275 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.884 |
| EGF | IGF1 | ENSSSCP00000028117 | ENSSSCP00000000915 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.980 |
| EGF | KIT | ENSSSCP00000028117 | ENSSSCP00000066488 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] | 0.956 |
| EGF | PDGFA | ENSSSCP00000028117 | ENSSSCP00000008054 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.919 |
| EGF | PDGFB | ENSSSCP00000028117 | ENSSSCP00000041857 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.950 |
| EGF | PDGFC | ENSSSCP00000028117 | ENSSSCP00000024797 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.929 |
| EGF | PDGFD | ENSSSCP00000028117 | ENSSSCP00000015918 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.935 |
| EGF | PDGFRA | ENSSSCP00000028117 | ENSSSCP00000048936 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.958 |
| EGF | PDGFRB | ENSSSCP00000028117 | ENSSSCP00000015373 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.960 |
| FLT1 | EGF | ENSSSCP00000062931 | ENSSSCP00000028117 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | 0.917 |
| FLT1 | IGF1 | ENSSSCP00000062931 | ENSSSCP00000000915 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.915 |
| FLT1 | PDGFA | ENSSSCP00000062931 | ENSSSCP00000008054 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.932 |
| FLT1 | PDGFB | ENSSSCP00000062931 | ENSSSCP00000041857 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.942 |
| FLT1 | PDGFC | ENSSSCP00000062931 | ENSSSCP00000024797 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.957 |
| FLT1 | PDGFD | ENSSSCP00000062931 | ENSSSCP00000015918 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.937 |
| FLT1 | PDGFRB | ENSSSCP00000062931 | ENSSSCP00000015373 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.551 |
| FLT3 | EGF | ENSSSCP00000028275 | ENSSSCP00000028117 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | 0.884 |
| FLT3 | IGF1 | ENSSSCP00000028275 | ENSSSCP00000000915 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.904 |
| FLT3 | PDGFA | ENSSSCP00000028275 | ENSSSCP00000008054 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.943 |
