node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FH | NDUFS8 | ENSSSCP00000046547 | ENSSSCP00000056756 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | NADH dehydrogenase ubiquinone iron-sulfur protein 8, mitochondrial. | 0.432 |
FH | SDHA | ENSSSCP00000046547 | ENSSSCP00000026945 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |
FH | SDHB | ENSSSCP00000046547 | ENSSSCP00000071101 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.995 |
FH | SDHC | ENSSSCP00000046547 | ENSSSCP00000073139 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family. | 0.994 |
FH | SDHD | ENSSSCP00000046547 | ENSSSCP00000015958 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. | 0.987 |
FH | SUCLA2 | ENSSSCP00000046547 | ENSSSCP00000046548 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.792 |
FH | UQCRC2 | ENSSSCP00000046547 | ENSSSCP00000008374 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] | Cytochrome b-c1 complex subunit 2, mitochondrial; Belongs to the peptidase M16 family. | 0.855 |
NDUFA2 | NDUFA8 | ENSSSCP00000068738 | ENSSSCP00000005924 | NADH:ubiquinone oxidoreductase subunit A2. | CHCH domain-containing protein. | 0.999 |
NDUFA2 | NDUFB9 | ENSSSCP00000068738 | ENSSSCP00000030827 | NADH:ubiquinone oxidoreductase subunit A2. | NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. | 0.999 |
NDUFA2 | NDUFS8 | ENSSSCP00000068738 | ENSSSCP00000056756 | NADH:ubiquinone oxidoreductase subunit A2. | NADH dehydrogenase ubiquinone iron-sulfur protein 8, mitochondrial. | 0.999 |
NDUFA2 | SDHA | ENSSSCP00000068738 | ENSSSCP00000026945 | NADH:ubiquinone oxidoreductase subunit A2. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.638 |
NDUFA2 | SDHB | ENSSSCP00000068738 | ENSSSCP00000071101 | NADH:ubiquinone oxidoreductase subunit A2. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.912 |
NDUFA2 | SDHC | ENSSSCP00000068738 | ENSSSCP00000073139 | NADH:ubiquinone oxidoreductase subunit A2. | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family. | 0.915 |
NDUFA2 | SDHD | ENSSSCP00000068738 | ENSSSCP00000015958 | NADH:ubiquinone oxidoreductase subunit A2. | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. | 0.946 |
NDUFA2 | UQCRC2 | ENSSSCP00000068738 | ENSSSCP00000008374 | NADH:ubiquinone oxidoreductase subunit A2. | Cytochrome b-c1 complex subunit 2, mitochondrial; Belongs to the peptidase M16 family. | 0.967 |
NDUFA8 | NDUFA2 | ENSSSCP00000005924 | ENSSSCP00000068738 | CHCH domain-containing protein. | NADH:ubiquinone oxidoreductase subunit A2. | 0.999 |
NDUFA8 | NDUFB9 | ENSSSCP00000005924 | ENSSSCP00000030827 | CHCH domain-containing protein. | NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. | 0.999 |
NDUFA8 | NDUFS8 | ENSSSCP00000005924 | ENSSSCP00000056756 | CHCH domain-containing protein. | NADH dehydrogenase ubiquinone iron-sulfur protein 8, mitochondrial. | 0.999 |
NDUFA8 | SDHA | ENSSSCP00000005924 | ENSSSCP00000026945 | CHCH domain-containing protein. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.775 |
NDUFA8 | SDHB | ENSSSCP00000005924 | ENSSSCP00000071101 | CHCH domain-containing protein. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.944 |