node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLP2 | APP | ENSSSCP00000039142 | ENSSSCP00000012805 | Amyloid beta precursor like protein 2. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.722 |
APLP2 | BACE1 | ENSSSCP00000039142 | ENSSSCP00000016002 | Amyloid beta precursor like protein 2. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.784 |
APLP2 | BACE2 | ENSSSCP00000039142 | ENSSSCP00000012854 | Amyloid beta precursor like protein 2. | Beta-secretase 2 isoform A preproprotein; Belongs to the peptidase A1 family. | 0.551 |
APLP2 | IDE | ENSSSCP00000039142 | ENSSSCP00000011159 | Amyloid beta precursor like protein 2. | Insulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. | 0.639 |
APLP2 | PSEN1 | ENSSSCP00000039142 | ENSSSCP00000002538 | Amyloid beta precursor like protein 2. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.715 |
APP | APLP2 | ENSSSCP00000012805 | ENSSSCP00000039142 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Amyloid beta precursor like protein 2. | 0.722 |
APP | BACE1 | ENSSSCP00000012805 | ENSSSCP00000016002 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.968 |
APP | BACE2 | ENSSSCP00000012805 | ENSSSCP00000012854 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Beta-secretase 2 isoform A preproprotein; Belongs to the peptidase A1 family. | 0.712 |
APP | IDE | ENSSSCP00000012805 | ENSSSCP00000011159 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Insulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. | 0.940 |
APP | MMEL1 | ENSSSCP00000012805 | ENSSSCP00000068501 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Membrane metalloendopeptidase like 1. | 0.747 |
APP | PSEN1 | ENSSSCP00000012805 | ENSSSCP00000002538 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.992 |
BACE1 | APLP2 | ENSSSCP00000016002 | ENSSSCP00000039142 | Beta-secretase 1; Belongs to the peptidase A1 family. | Amyloid beta precursor like protein 2. | 0.784 |
BACE1 | APP | ENSSSCP00000016002 | ENSSSCP00000012805 | Beta-secretase 1; Belongs to the peptidase A1 family. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.968 |
BACE1 | BACE2 | ENSSSCP00000016002 | ENSSSCP00000012854 | Beta-secretase 1; Belongs to the peptidase A1 family. | Beta-secretase 2 isoform A preproprotein; Belongs to the peptidase A1 family. | 0.905 |
BACE1 | GGA1 | ENSSSCP00000016002 | ENSSSCP00000044208 | Beta-secretase 1; Belongs to the peptidase A1 family. | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. | 0.850 |
BACE1 | IDE | ENSSSCP00000016002 | ENSSSCP00000011159 | Beta-secretase 1; Belongs to the peptidase A1 family. | Insulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. | 0.858 |
BACE1 | MMEL1 | ENSSSCP00000016002 | ENSSSCP00000068501 | Beta-secretase 1; Belongs to the peptidase A1 family. | Membrane metalloendopeptidase like 1. | 0.858 |
BACE1 | PSEN1 | ENSSSCP00000016002 | ENSSSCP00000002538 | Beta-secretase 1; Belongs to the peptidase A1 family. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.850 |
BACE1 | RTN2 | ENSSSCP00000016002 | ENSSSCP00000073525 | Beta-secretase 1; Belongs to the peptidase A1 family. | Reticulon. | 0.750 |
BACE1 | RTN3 | ENSSSCP00000016002 | ENSSSCP00000013880 | Beta-secretase 1; Belongs to the peptidase A1 family. | Reticulon. | 0.968 |