CHEK1 protein (Sus scrofa) - STRING interaction network

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Score

CHEK1

Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)

Predicted Functional Partners:

ATR

0.995

CHEK2

0.989

CDC25C

0.984

CDC25A

0.984

CLSPN

0.980

TP53

0.977

CDC25B

0.976

ATM

0.961

WEE1

0.958

MCM4

0.958

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSSSCP00000015931	ENSSSCP00000012449	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.997
ATM	CDC25A	ENSSSCP00000015931	ENSSSCP00000050712	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	M-phase inducer phosphatase 1 isoform a.	0.642
ATM	CDC25C	ENSSSCP00000015931	ENSSSCP00000015242	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity).	0.621
ATM	CHEK1	ENSSSCP00000015931	ENSSSCP00000016136	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily.	0.961
ATM	CHEK2	ENSSSCP00000015931	ENSSSCP00000039835	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Serine/threonine-protein kinase Chk2 isoform X4.	0.993
ATM	CLSPN	ENSSSCP00000015931	ENSSSCP00000032585	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Claspin.	0.669
ATM	TP53	ENSSSCP00000015931	ENSSSCP00000050664	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.997
ATM	WEE1	ENSSSCP00000015931	ENSSSCP00000014257	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	Wee1-like protein kinase.	0.597
ATR	ATM	ENSSSCP00000012449	ENSSSCP00000015931	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	0.997
ATR	CDC25A	ENSSSCP00000012449	ENSSSCP00000050712	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	M-phase inducer phosphatase 1 isoform a.	0.665
ATR	CDC25C	ENSSSCP00000012449	ENSSSCP00000015242	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity).	0.665
ATR	CHEK1	ENSSSCP00000012449	ENSSSCP00000016136	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily.	0.995
ATR	CHEK2	ENSSSCP00000012449	ENSSSCP00000039835	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk2 isoform X4.	0.993
ATR	CLSPN	ENSSSCP00000012449	ENSSSCP00000032585	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Claspin.	0.725
ATR	MCM4	ENSSSCP00000012449	ENSSSCP00000047671	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.697
ATR	TP53	ENSSSCP00000012449	ENSSSCP00000050664	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.968
ATR	WEE1	ENSSSCP00000012449	ENSSSCP00000014257	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Wee1-like protein kinase.	0.430
CDC25A	ATM	ENSSSCP00000050712	ENSSSCP00000015931	M-phase inducer phosphatase 1 isoform a.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]	0.642
CDC25A	ATR	ENSSSCP00000050712	ENSSSCP00000012449	M-phase inducer phosphatase 1 isoform a.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.665
CDC25A	CDC25B	ENSSSCP00000050712	ENSSSCP00000050117	M-phase inducer phosphatase 1 isoform a.	M-phase inducer phosphatase 2 isoform 1.	0.910