HGF protein (Sus scrofa) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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Score

HGF

Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)

Predicted Functional Partners:

MET

0.999

EGF

0.981

IGF1

0.979

VEGFD

0.941

PDGFA

0.923

ERBB3

0.922

VEGFB

0.919

PDGFC

0.909

FGF2

0.879

EGFR

0.874

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	EGFR	ENSSSCP00000028117	ENSSSCP00000068369	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Receptor protein-tyrosine kinase.	0.999
EGF	ERBB3	ENSSSCP00000028117	ENSSSCP00000019799	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Erb-b2 receptor tyrosine kinase 3.	0.985
EGF	FGF2	ENSSSCP00000028117	ENSSSCP00000055271	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.939
EGF	HGF	ENSSSCP00000028117	ENSSSCP00000016330	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.981
EGF	IGF1	ENSSSCP00000028117	ENSSSCP00000000915	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.989
EGF	MET	ENSSSCP00000028117	ENSSSCP00000017620	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.771
EGF	PDGFA	ENSSSCP00000028117	ENSSSCP00000008054	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.	0.931
EGF	PDGFC	ENSSSCP00000028117	ENSSSCP00000024797	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.907
EGF	VEGFB	ENSSSCP00000028117	ENSSSCP00000013864	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.926
EGF	VEGFD	ENSSSCP00000028117	ENSSSCP00000012918	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family.	0.919
EGFR	EGF	ENSSSCP00000068369	ENSSSCP00000028117	Receptor protein-tyrosine kinase.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).	0.999
EGFR	ERBB3	ENSSSCP00000068369	ENSSSCP00000019799	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.982
EGFR	FGF2	ENSSSCP00000068369	ENSSSCP00000055271	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.703
EGFR	HGF	ENSSSCP00000068369	ENSSSCP00000016330	Receptor protein-tyrosine kinase.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.874
EGFR	IGF1	ENSSSCP00000068369	ENSSSCP00000000915	Receptor protein-tyrosine kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.962
EGFR	MET	ENSSSCP00000068369	ENSSSCP00000017620	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.781
EGFR	PDGFA	ENSSSCP00000068369	ENSSSCP00000008054	Receptor protein-tyrosine kinase.	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.	0.930
EGFR	PDGFC	ENSSSCP00000068369	ENSSSCP00000024797	Receptor protein-tyrosine kinase.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.935
EGFR	VEGFB	ENSSSCP00000068369	ENSSSCP00000013864	Receptor protein-tyrosine kinase.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.697
EGFR	VEGFD	ENSSSCP00000068369	ENSSSCP00000012918	Receptor protein-tyrosine kinase.	Vascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family.	0.688