node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEST2 | GLUL | ENSSSCP00000014603 | ENSSSCP00000042620 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.974 |
CAD | CPS1 | ENSSSCP00000025052 | ENSSSCP00000051055 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Carbamoyl-phosphate synthase 1. | 0.903 |
CAD | GAD2 | ENSSSCP00000025052 | ENSSSCP00000011796 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.828 |
CAD | GFPT1 | ENSSSCP00000025052 | ENSSSCP00000035420 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine--fructose-6-phosphate transaminase 1. | 0.924 |
CAD | GFPT2 | ENSSSCP00000025052 | ENSSSCP00000037166 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine--fructose-6-phosphate aminotransferase isomerizing 2. | 0.924 |
CAD | GLS | ENSSSCP00000025052 | ENSSSCP00000055263 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutaminase. | 0.904 |
CAD | GLS2 | ENSSSCP00000025052 | ENSSSCP00000000427 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutaminase 2. | 0.904 |
CAD | GLUD1 | ENSSSCP00000025052 | ENSSSCP00000011056 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.530 |
CAD | GLUL | ENSSSCP00000025052 | ENSSSCP00000042620 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.952 |
CAD | PPAT | ENSSSCP00000025052 | ENSSSCP00000009497 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.986 |
CPS1 | CAD | ENSSSCP00000051055 | ENSSSCP00000025052 | Carbamoyl-phosphate synthase 1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.903 |
CPS1 | GLS | ENSSSCP00000051055 | ENSSSCP00000055263 | Carbamoyl-phosphate synthase 1. | Glutaminase. | 0.907 |
CPS1 | GLS2 | ENSSSCP00000051055 | ENSSSCP00000000427 | Carbamoyl-phosphate synthase 1. | Glutaminase 2. | 0.917 |
CPS1 | GLUD1 | ENSSSCP00000051055 | ENSSSCP00000011056 | Carbamoyl-phosphate synthase 1. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.974 |
CPS1 | GLUL | ENSSSCP00000051055 | ENSSSCP00000042620 | Carbamoyl-phosphate synthase 1. | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] | 0.965 |
CPS1 | PPAT | ENSSSCP00000051055 | ENSSSCP00000009497 | Carbamoyl-phosphate synthase 1. | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.711 |
GAD2 | CAD | ENSSSCP00000011796 | ENSSSCP00000025052 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.828 |
GAD2 | GLS | ENSSSCP00000011796 | ENSSSCP00000055263 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | Glutaminase. | 0.942 |
GAD2 | GLS2 | ENSSSCP00000011796 | ENSSSCP00000000427 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | Glutaminase 2. | 0.935 |
GAD2 | GLUD1 | ENSSSCP00000011796 | ENSSSCP00000011056 | Glutamate decarboxylase 2; Catalyzes the production of GABA. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). | 0.936 |