Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PTPN18Tyrosine-protein phosphatase non-receptor type 18 isoform X1. (454 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
    
 0.879
PSTPIP1
Proline-serine-threonine phosphatase interacting protein 1.
   
 
 0.847
ERBB2
Receptor protein-tyrosine kinase.
    
 0.796
AKTIP
AKT-interacting protein isoform 1.
      
 0.689
MED22
Mediator complex subunit 22.
      
 0.685
DAPP1
Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.
   
 
 0.649
PPP1R9B
Protein phosphatase 1 regulatory subunit 9B.
      
 0.640
RNGTT
Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
      
 0.626
FRMPD2
FERM and PDZ domain containing 2.
 
      0.619
GOPC
PDZ domain-containing protein.
   
  
 0.606
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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