| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARPC5L | SPCS2 | ENSSSCP00000005995 | ENSSSCP00000015769 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. | Signal peptidase complex subunit 2. | 0.652 |
| ARPC5L | SPCS3 | ENSSSCP00000005995 | ENSSSCP00000016709 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. | Signal peptidase complex subunit 3. | 0.672 |
| GRP | SPCS1 | ENSSSCP00000045701 | ENSSSCP00000012199 | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.766 |
| GRP | SPCS2 | ENSSSCP00000045701 | ENSSSCP00000015769 | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. | Signal peptidase complex subunit 2. | 0.812 |
| GRP | SPCS3 | ENSSSCP00000045701 | ENSSSCP00000016709 | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. | Signal peptidase complex subunit 3. | 0.755 |
| MRPS18B | SPCS3 | ENSSSCP00000024944 | ENSSSCP00000016709 | 28S ribosomal protein S18b, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily. | Signal peptidase complex subunit 3. | 0.698 |
| SEC11A | SEC11C | ENSSSCP00000067544 | ENSSSCP00000005285 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex catalytic subunit SEC11. | 0.653 |
| SEC11A | SPCS1 | ENSSSCP00000067544 | ENSSSCP00000012199 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.931 |
| SEC11A | SPCS2 | ENSSSCP00000067544 | ENSSSCP00000015769 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex subunit 2. | 0.981 |
| SEC11A | SPCS3 | ENSSSCP00000067544 | ENSSSCP00000016709 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex subunit 3. | 0.974 |
| SEC11C | SEC11A | ENSSSCP00000005285 | ENSSSCP00000067544 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex catalytic subunit SEC11. | 0.653 |
| SEC11C | SPCS1 | ENSSSCP00000005285 | ENSSSCP00000012199 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.924 |
| SEC11C | SPCS2 | ENSSSCP00000005285 | ENSSSCP00000015769 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex subunit 2. | 0.955 |
| SEC11C | SPCS3 | ENSSSCP00000005285 | ENSSSCP00000016709 | Signal peptidase complex catalytic subunit SEC11. | Signal peptidase complex subunit 3. | 0.929 |
| SEC63 | SPCS1 | ENSSSCP00000004730 | ENSSSCP00000012199 | SEC63 homolog, protein translocation regulator. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.781 |
| SEC63 | SPCS2 | ENSSSCP00000004730 | ENSSSCP00000015769 | SEC63 homolog, protein translocation regulator. | Signal peptidase complex subunit 2. | 0.592 |
| SEC63 | SPCS3 | ENSSSCP00000004730 | ENSSSCP00000016709 | SEC63 homolog, protein translocation regulator. | Signal peptidase complex subunit 3. | 0.695 |
| SEC63 | SRP19 | ENSSSCP00000004730 | ENSSSCP00000022214 | SEC63 homolog, protein translocation regulator. | Signal recognition particle 19 kDa protein isoform 1. | 0.485 |
| SEC63 | SRP72 | ENSSSCP00000004730 | ENSSSCP00000009492 | SEC63 homolog, protein translocation regulator. | Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. | 0.607 |
| SPCS1 | GRP | ENSSSCP00000012199 | ENSSSCP00000045701 | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. | 0.766 |