STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)    
Predicted Functional Partners:
PLEKHA2
Pleckstrin homology domain containing A2.
      
 0.581
PRCD
Photoreceptor disc component.
      
 0.564
TM2D2
TM2 domain-containing protein 2 isoform a.
   
  
 0.552
IQSEC2
IQ motif and Sec7 domain 2.
      
 0.530
AVL9
AVL9 cell migration associated.
      
 0.517
CCDC66
Coiled-coil domain containing 66.
      
 0.511
RD3
Retinal degeneration 3, GUCY2D regulator.
      
 0.490
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membra [...]
   
  
0.489
FUT11
Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family.
      
 0.489
APH1B
Aph-1 homolog B, gamma-secretase subunit.
      
 0.483
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.