STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAPGEF4Rap guanine nucleotide exchange factor 4. (995 aa)    
Predicted Functional Partners:
RAP1A
RAP1A, member of RAS oncogene family.
    
 0.914
ABCC8
ATP binding cassette subfamily C member 8.
    
 0.854
RAP1B
RAP1B, member of RAS oncogene family.
    
 0.829
KCNJ11
Potassium voltage-gated channel subfamily J member 11.
   
 
 0.772
CWC27
Peptidyl-prolyl cis-trans isomerase CWC27 homolog isoform 1.
    
 
 0.716
TMEM116
Transmembrane protein 116 isoform X4.
      
 0.707
MOCS2
Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily.
      
 0.624
IPO11
Importin 11.
      
 0.614
HOMER2
Homer scaffold protein 2.
      
 0.597
ZNF704
Zinc finger protein 704 isoform X1.
      
 0.582
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.