HOXD1 protein (Sus scrofa) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

HOXD1

Homeobox D1. (327 aa)

Predicted Functional Partners:

HOXB1

0.919

HOXA1

0.903

SPRY1

0.579

IRX3

0.541

FLT4

0.508

PRRG1

0.489

A0A287ABX1_PIG

0.489

MTX2

0.473

NIPAL2

0.463

ANGPT2

0.454

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A287ABX1_PIG	HOXD1	ENSSSCP00000041380	ENSSSCP00000016938	Gla domain-containing protein.	Homeobox D1.	0.489
ANGPT2	FLT4	ENSSSCP00000067734	ENSSSCP00000014892	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.876
ANGPT2	HOXD1	ENSSSCP00000067734	ENSSSCP00000016938	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	Homeobox D1.	0.454
FLT4	ANGPT2	ENSSSCP00000014892	ENSSSCP00000067734	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	0.876
FLT4	HOXD1	ENSSSCP00000014892	ENSSSCP00000016938	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Homeobox D1.	0.508
FLT4	SPRY1	ENSSSCP00000014892	ENSSSCP00000067830	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Sprouty RTK signaling antagonist 1.	0.485
HOXA1	HOXB1	ENSSSCP00000017697	ENSSSCP00000018580	Homeobox protein Hox-A1 isoform X1.	Homeobox protein Hox-B1.	0.916
HOXA1	HOXD1	ENSSSCP00000017697	ENSSSCP00000016938	Homeobox protein Hox-A1 isoform X1.	Homeobox D1.	0.903
HOXB1	HOXA1	ENSSSCP00000018580	ENSSSCP00000017697	Homeobox protein Hox-B1.	Homeobox protein Hox-A1 isoform X1.	0.916
HOXB1	HOXD1	ENSSSCP00000018580	ENSSSCP00000016938	Homeobox protein Hox-B1.	Homeobox D1.	0.919
HOXD1	A0A287ABX1_PIG	ENSSSCP00000016938	ENSSSCP00000041380	Homeobox D1.	Gla domain-containing protein.	0.489
HOXD1	ANGPT2	ENSSSCP00000016938	ENSSSCP00000067734	Homeobox D1.	Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).	0.454
HOXD1	FLT4	ENSSSCP00000016938	ENSSSCP00000014892	Homeobox D1.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.508
HOXD1	HOXA1	ENSSSCP00000016938	ENSSSCP00000017697	Homeobox D1.	Homeobox protein Hox-A1 isoform X1.	0.903
HOXD1	HOXB1	ENSSSCP00000016938	ENSSSCP00000018580	Homeobox D1.	Homeobox protein Hox-B1.	0.919
HOXD1	IRX3	ENSSSCP00000016938	ENSSSCP00000003051	Homeobox D1.	Iroquois-class homeodomain protein IRX-3 isoform X2.	0.541
HOXD1	MTX2	ENSSSCP00000016938	ENSSSCP00000027271	Homeobox D1.	Metaxin-2; Involved in transport of proteins into the mitochondrion.	0.473
HOXD1	NIPAL2	ENSSSCP00000016938	ENSSSCP00000053861	Homeobox D1.	NIPA like domain containing 2.	0.463
HOXD1	PRRG1	ENSSSCP00000016938	ENSSSCP00000025407	Homeobox D1.	Transmembrane gamma-carboxyglutamic acid protein 1 isoform 1.	0.489
HOXD1	SPRY1	ENSSSCP00000016938	ENSSSCP00000067830	Homeobox D1.	Sprouty RTK signaling antagonist 1.	0.579